C
Chongyuan Luo
Researcher at University of California, Los Angeles
Publications - 62
Citations - 6054
Chongyuan Luo is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Chromatin & Epigenomics. The author has an hindex of 24, co-authored 55 publications receiving 3846 citations. Previous affiliations of Chongyuan Luo include Spanish National Research Council & University of California, Berkeley.
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Journal ArticleDOI
Phased diploid genome assembly with single-molecule real-time sequencing
Chen-Shan Chin,Paul Peluso,Fritz J. Sedlazeck,Maria Nattestad,Gregory T. Concepcion,Alicia Clum,Christopher Dunn,Ronan C. O'Malley,Rosa Figueroa-Balderas,Abraham Morales-Cruz,Grant R. Cramer,Massimo Delledonne,Chongyuan Luo,Joseph R. Ecker,Dario Cantu,David R. Rank,Michael C. Schatz,Michael C. Schatz +17 more
TL;DR: The open-source FALCON and FALcon-Unzip algorithms are introduced to assemble long-read sequencing data into highly accurate, contiguous, and correctly phased diploid genomes.
Journal ArticleDOI
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
Alisa Mo,Eran A. Mukamel,Eran A. Mukamel,Fred P. Davis,Chongyuan Luo,Gilbert L. Henry,Serge Picard,Mark A. Urich,Joseph R. Nery,Terrence J. Sejnowski,Terrence J. Sejnowski,Ryan Lister,Ryan Lister,Sean R. Eddy,Joseph R. Ecker,Jeremy Nathans +15 more
TL;DR: The first affinity purification approach to isolate nuclei from genetically defined cell types in a mammal is developed and this technique is combined with next-generation sequencing to show that three subtypes of neocortical neurons have highly distinctive epigenomic landscapes.
Journal ArticleDOI
Single-cell methylomes identify neuronal subtypes and regulatory elements in mammalian cortex
Chongyuan Luo,Christopher L. Keown,Laurie Kurihara,Jingtian Zhou,Jingtian Zhou,Yupeng He,Yupeng He,Jun-Hao Li,Rosa Castanon,Jacinta Lucero,Joseph R. Nery,Justin P. Sandoval,Brian Bui,Terrence J. Sejnowski,Terrence J. Sejnowski,Timothy T. Harkins,Eran A. Mukamel,M. Margarita Behrens,Joseph R. Ecker +18 more
TL;DR: A comprehensive map of methylation variation in neuronal cell populations, including a between-species comparison, illustrates how epigenetic diversity plays important roles in neuronal development.
Journal ArticleDOI
Dynamic DNA methylation: In the right place at the right time
TL;DR: Recent findings that delineate 5mC functions in developmental stages and diverse genomic compartments are reviewed as well as discuss the molecular mechanisms that connect transcriptional regulation and5mC.
Journal ArticleDOI
Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain
Chongyuan Luo,Madeline A. Lancaster,Rosa Castanon,Joseph R. Nery,Juergen A. Knoblich,Joseph R. Ecker +5 more
TL;DR: This study reveals that organoids recapitulate many epigenomic features of mid-fetal human brain and also identified novel non-CG methylation signatures of brain development.