J
Ju Lu
Researcher at University of California, Santa Cruz
Publications - 15
Citations - 957
Ju Lu is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Dendritic spine & Sensory system. The author has an hindex of 9, co-authored 15 publications receiving 671 citations. Previous affiliations of Ju Lu include Stanford University.
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Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo.
TL;DR: These findings suggest that clustering of new synapses along dendrites is induced by repetitive activation of the cortical circuitry during learning, providing a structural basis for spatial coding of motor memory in the mammalian brain.
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A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.
Journal ArticleDOI
Spatiotemporal dynamics of dendritic spines in the living brain
Chia-Chien Chen,Ju Lu,Yi Zuo +2 more
TL;DR: It is believed that better understanding of the spatiotemporal patterns of spine dynamics will help elucidate the principles of experience-dependent circuit modification and information processing in the living brain.
Journal ArticleDOI
Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects.
TL;DR: It is suggested that the PV+ inhibitory circuit is crucial for normal synaptic dynamics in the mouse barrel cortex and sensory function and pharmacological, pharmacogenetic and environmental approaches to prevent stress-induced maladaptive behaviors and synaptic malfunctions converge on the regulation of PV+ IN activity.
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Locus coeruleus-norepinephrine modulation of sensory processing and perception: A focused review.
TL;DR: The consistent as well as seemingly inconsistent findings across brain areas and sensory modalities are summarized and a framework to understand these phenomena from the perspective of adrenergic receptor expression, dose-dependent physiology and excitation-inhibition balance is proposed.