D
Douglas Myers-Turnbull
Researcher at University of California, San Francisco
Publications - 9
Citations - 299
Douglas Myers-Turnbull is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Inclusion (education) & GABAA receptor. The author has an hindex of 6, co-authored 9 publications receiving 148 citations. Previous affiliations of Douglas Myers-Turnbull include University of California, Berkeley & University of California, San Diego.
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Journal ArticleDOI
A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.
Journal ArticleDOI
Systematic detection of internal symmetry in proteins using CE-Symm.
Douglas Myers-Turnbull,Spencer Bliven,Peter W. Rose,Zaid K. Aziz,Philippe Youkharibache,Philip E. Bourne,Andreas Prlić +6 more
TL;DR: An algorithm, CE-Symm, is developed to detect pseudo-symmetry within the tertiary structure of protein chains and provides a methodology for a more complete and detailed study of the role of symmetry in tertiary protein structure.
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Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.
Lee E. Dunlap,Arya Azinfar,Calvin Ly,Lindsay P. Cameron,Jayashri Viswanathan,Robert J. Tombari,Douglas Myers-Turnbull,Jack C. Taylor,Ana Cristina Grodzki,Pamela J. Lein,David Kokel,David E. Olson +11 more
TL;DR: This work has discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N,N-dimethylaminoisotryptamine (isoDMT) Psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.
Journal ArticleDOI
BioJava 5: A community driven open-source bioinformatics library
Aleix Lafita,Spencer Bliven,Andreas Prlić,Dmytro Guzenko,Peter W. Rose,Anthony R. Bradley,Anthony R. Bradley,Paolo Pavan,Douglas Myers-Turnbull,Yana Valasatava,Michael Heuer,Matthew R. Larson,Stephen K. Burley,Stephen K. Burley,Jose M. Duarte +14 more
TL;DR: The project aims to simplify bioinformatic analyses by implementing parsers, data structures, and algorithms for common tasks in genomics, structural biology, ontologies, phylogenetics, and more.
Journal ArticleDOI
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
Matthew N. McCarroll,Leo Gendelev,Reid Kinser,Jack C. Taylor,Giancarlo N. Bruni,Douglas Myers-Turnbull,Cole Helsell,Amanda Carbajal,Capria Rinaldi,Hye Jin Kang,Jung Ho Gong,Jason K. Sello,Susumu Tomita,Randall T. Peterson,Randall T. Peterson,Michael J. Keiser,David Kokel +16 more
TL;DR: It is shown that a subset of central nervous system depressants cause paradoxical excitation in zebrafish, and dozens of compounds that generally decrease neuronal activity, but increase activity in the caudal hindbrain of zebra fish are identified.