Robert J. Tombari

TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.

TL;DR: This work has discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N,N-dimethylaminoisotryptamine (isoDMT) Psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.

TL;DR: In this article , the role of location bias in 5-HT2AR signaling, and the intriguing possibility that serotonin might not be the endogenous ligand for intracellular 5-H2ARs in the cortex.

TL;DR: In this paper, the authors utilize azide-alkyne click chemistry to access arylazo-1,2,3-triazoles, a previously unexplored class of azoheteroarenes that exhibit high thermal stabilities and near-quantitative bidirectional photoconversion.

TL;DR: This study uses quantum chemical calculations to predict 1H and 13C chemical shifts for serlyticin-A and demonstrates a discrepancy between the calculated and experimental chemical shifts, highlighting the power of computational NMR shift prediction to revise chemical structures for natural products like Serlytic in-A.