M
Michelle Tjia
Researcher at University of California, Santa Cruz
Publications - 8
Citations - 293
Michelle Tjia is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Dendritic spine & Vestibular system. The author has an hindex of 5, co-authored 7 publications receiving 134 citations. Previous affiliations of Michelle Tjia include University of California, Irvine.
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Journal ArticleDOI
A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.
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Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome
Jennifer L. Hodges,Xinzhu Yu,Anthony Gilmore,Hannah Bennett,Michelle Tjia,James F. Perna,Chia Chien Chen,Xiang Li,Ju Lu,Yi Zuo +9 more
TL;DR: This work suggests a joint astrocytic-neuronal contribution to FXS pathogenesis and reveals that heightened spine formation during adolescence precedes the overabundance of spines and behavioral defects found in adult Fmr1 KO mice.
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Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines.
TL;DR: Data reveal distinct dynamics and plasticity of apical dendritic spines on PNs in different layers in the living mouse cortex, which may arise from their distinct functional roles in cortical circuits.
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An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress.
Ju Lu,Michelle Tjia,Brian R. Mullen,Bing Cao,Kacper Lukasiewicz,Sajita Shah-Morales,Sydney Weiser,Lindsay P. Cameron,David E. Olson,Lu Chen,Yi Zuo +10 more
TL;DR: In this article, the effects of mild stress on cortical neuronal circuit activity patterns and demonstrate that TBG combats the detrimental effects of stress by modulating basal and stimulus-dependent neural activity in cortical networks.
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Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly
TL;DR: In this paper , the authors discuss the importance of the synaptic excitation/inhibition (E/I) balance in the context of homeostatic plasticity, whose primary goal is thought to maintain neuronal firing rates at a set point.