Lauren J. Laskowski

TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.

TL;DR: The tryptamine derivatives have psilocybin-like pharmacological properties, supporting their classification as psychedelic drugs.

TL;DR: This article found that transient receptor potential canonical 5 (TRPC5) is a chief contributor to both of these sensations in multiple rodent pain models and that TRPC5 selectively contributes to the mechanical hypersensitivity associated with CFA injection, skin incision, chemotherapy induced peripheral neuropathy, sickle cell disease, and migraine.

TL;DR: Five mutations in the C3aR1 binding pocket of the rodent Murinae subfamily that are causal for enhanced calculated affinity and measured potency of TLQP-21 are uncovered.

TL;DR: NMR experiments on 13CH3-ε-methionine-labeled ACKR3 reveal that β-arrestin recruitment is associated with conformational exchange at key regions of the extracellular ligand-binding pocket and intracellular β-Arrestin-coupling region.