L
Lee E. Dunlap
Researcher at University of California, Davis
Publications - 11
Citations - 425
Lee E. Dunlap is an academic researcher from University of California, Davis. The author has contributed to research in topics: Hallucinogen & Medicine. The author has an hindex of 5, co-authored 9 publications receiving 141 citations.
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Journal ArticleDOI
A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.
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Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression.
TL;DR: It is found that while DMT elicits initial anxiogenic responses in several of these paradigms, its long-lasting effects tend to reduce anxiety by facilitating the extinction of cued fear memory, and DMT reduces immobility in the forced swim test, which is a characteristic behavioral response induced by many antidepressants.
Journal ArticleDOI
Psychedelic-inspired drug discovery using an engineered biosensor
Chunyang Dong,Calvin Ly,Lee E. Dunlap,Maxemiliano V. Vargas,Junqing Sun,In-Wook Hwang,Arya Azinfar,Won Chan Oh,William C. Wetsel,David E. Olson,Lin Tian +10 more
TL;DR: In this article, a genetically encoded fluorescent sensor based on the 5-HT2AR structure was developed to detect behaviorally relevant serotonin release and correctly predicts the hallucinogenic behavioral effects of structurally similar 5-H2AR ligands.
Journal ArticleDOI
Psychedelic-Inspired Drug Discovery Using an Engineered Biosensor
Chunyang Dong,Calvin Ly,Lee E. Dunlap,Maxemiliano V. Vargas,Junqing Sun,In-Wook Hwang,Arya Azinfar,Won Chan Oh,William C. Wetsel,David E. Olson,Lin Tian +10 more
TL;DR: In this paper, a genetically-encoded fluorescent sensor based on the 5-hydroxytryptamine 2A (5-HT2AR) structure was developed to report behaviorally-relevant serotonin release and 5-HT 2AR conformations induced by serotonergic hallucinogens.
Journal ArticleDOI
Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine
TL;DR: The synthesis of MDMA is detailed as well as its pharmacology, metabolism, adverse effects, and potential use in medicine, which discusses its history and why it is perhaps the most important compound for the future of psychedelic science.