J
Julie M. Decker
Researcher at University of Alabama at Birmingham
Publications - 60
Citations - 16331
Julie M. Decker is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 47, co-authored 60 publications receiving 15589 citations. Previous affiliations of Julie M. Decker include Howard Hughes Medical Institute & University of California, Los Angeles.
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Journal ArticleDOI
Antibody neutralization and escape by HIV-1
Xiping Wei,Julie M. Decker,Shuyi Wang,Huxiong Hui,John C. Kappes,Xiaoyun Wu,Jesus F. Salazar-Gonzalez,Maria G. Salazar,J. Michael Kilby,Michael S. Saag,Natalia L. Komarova,Martin A. Nowak,Beatrice H. Hahn,Peter D. Kwong,George M. Shaw +14 more
TL;DR: The detection of autologous Nab as early as 52 days after detection of HIV-specific antibodies is reported, indicating a new mechanism contributing to HIV-1 persistence in the face of an evolving antibody repertoire.
Journal ArticleDOI
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Brandon F. Keele,Elena E. Giorgi,Elena E. Giorgi,Jesus F. Salazar-Gonzalez,Julie M. Decker,Kimmy T. Pham,Maria G. Salazar,Chuanxi Sun,Truman Grayson,Shuyi Wang,Hui Li,Xiping Wei,Chunlai Jiang,Jennifer L. Kirchherr,Feng Gao,Jeffery A. Anderson,Li Hua Ping,Ronald Swanstrom,Georgia D. Tomaras,William A. Blattner,Paul A. Goepfert,J. Michael Kilby,Michael S. Saag,Eric Delwart,Michael P. Busch,Myron S. Cohen,David C. Montefiori,Barton F. Haynes,Brian Gaschen,Gayathri Athreya,Ha Y. Lee,Natasha T. Wood,Cathal Seoighe,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +39 more
TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
Journal ArticleDOI
Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy
Xiping Wei,Julie M. Decker,Hongmei Liu,Zee Zhang,Ramin B. Arani,J. Michael Kilby,Michael S. Saag,Xiaoyun Wu,George M. Shaw,John C. Kappes,John C. Kappes +10 more
TL;DR: These findings provide the first evidence for the rapid emergence of clinical resistance to a novel class of HIV-1 entry inhibitors and may be relevant to future treatment strategies involving these agents.
Journal ArticleDOI
Human Immunodeficiency Virus Type 1 env Clones from Acute and Early Subtype B Infections for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies
Ming Li,Feng Gao,John R. Mascola,Leonidas Stamatatos,Victoria R. Polonis,Marguerite Koutsoukos,Gerald Voss,Paul A. Goepfert,Peter B. Gilbert,Kelli Greene,Miroslawa Bilska,Denise Kothe,Jesus F. Salazar-Gonzalez,Xiping Wei,Julie M. Decker,Beatrice H. Hahn,David C. Montefiori +16 more
TL;DR: There is an urgent need to establish standard panels of HIV-1 reference strains for wide distribution and a lack of uniformity in target strains used by different investigators to assess cross-neutralization has made the comparison of vaccine-induced antibody responses difficult.
Journal ArticleDOI
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.
Jesus F. Salazar-Gonzalez,Maria G. Salazar,Brandon F. Keele,Gerald H. Learn,Elena E. Giorgi,Elena E. Giorgi,Hui Li,Julie M. Decker,Shuyi Wang,Joshua Baalwa,Matthias H. Kraus,Nicholas F. Parrish,Katharina S. Shaw,M. Brad Guffey,Katharine J. Bar,Katie L. Davis,Christina Ochsenbauer-Jambor,John C. Kappes,Michael S. Saag,Myron S. Cohen,Joseph Mulenga,Cynthia A. Derdeyn,Susan Allen,Eric Hunter,Martin Markowitz,Martin Markowitz,Peter T. Hraber,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Barton F. Haynes,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +34 more
TL;DR: Viral properties associated with mucosal HIV-1 transmission and a limited set of rapidly evolving adaptive mutations driven primarily, but not exclusively, by early cytotoxic T cell responses are revealed.