Truman Grayson

TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.

TL;DR: The molecular features of simian immunodeficiency virus (SIV) transmission in 18 experimentally infected Indian rhesus macaques are determined to validate the SIV–macaque mucosal infection model for HIV-1 vaccine and microbicide research.

TL;DR: It is shown by single-genome amplification and sequencing in a different IDU cohort that 60% of IDU subjects were infected by more than one virus, including one subject who was acutely infected by at least 16 viruses.

TL;DR: A randomized double-blind placebo-controlled phase 2 clinical trial ( NCT02372253 ) was conducted to assess the efficacy and safety of oral verapamil added for 12 months to a standard insulin regimen in adult subjects with recent-onset Type 1 diabetes as mentioned in this paper.

TL;DR: The present studies show for the first time that GLP1R is under the control of a microRNA, miR-204, and uncover a previously unappreciated link between TXNIP and incretin action.