J
Julie M. Decker
Researcher at University of Alabama at Birmingham
Publications - 60
Citations - 16331
Julie M. Decker is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 47, co-authored 60 publications receiving 15589 citations. Previous affiliations of Julie M. Decker include Howard Hughes Medical Institute & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Generation of Infectious Molecular Clones of Simian Immunodeficiency Virus from Fecal Consensus Sequences of Wild Chimpanzees
Jun Takehisa,Matthias H. Kraus,Julie M. Decker,Yingying Li,Brandon F. Keele,Frederic Bibollet-Ruche,Kenneth P. Zammit,Zhiping Weng,Mario L. Santiago,Shadrack Kamenya,Michael L. Wilson,Anne E. Pusey,Elizabeth Bailes,Paul M. Sharp,George M. Shaw,Beatrice H. Hahn +15 more
TL;DR: These results provide the first direct evidence that naturally occurring SIVcpz strains already have many of the biological properties required for persistent infection of humans, including CD4 and CCR5 dependence and neutralization resistance.
Journal ArticleDOI
Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
Chunlai Jiang,Nicholas F. Parrish,Craig B. Wilen,Hui Li,Yi Chen,Jeffrey W. Pavlicek,Anna Berg,Xusheng Lü,Hongshuo Song,John C. Tilton,John C. Tilton,Jennifer M. Pfaff,Elizabeth A. Henning,Julie M. Decker,M. A. Moody,Mark S. Drinker,Robert J. Schutte,Stephanie A. Freel,Georgia D. Tomaras,Rebecca Nedellec,Donald E. Mosier,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Robert W. Doms,Feng Gao +25 more
TL;DR: Results suggest that the ZP6248 T/F virus established an acute in vivo infection by using coreceptor(s) other than C CR5 or CXCR4 or that the CCR5 coreceptor existed in an unusual conformation in this individual.
Journal ArticleDOI
Broad and Potent Neutralizing Antibody Responses Elicited in Natural HIV-2 Infection
Rui Kong,Hui Li,Frederic Bibollet-Ruche,Julie M. Decker,Natalie N. Zheng,Geoffrey S. Gottlieb,Nancy B. Kiviat,Papa Salif Sow,Ivelin S. Georgiev,Beatrice H. Hahn,Peter D. Kwong,James E. Robinson,George M. Shaw +12 more
TL;DR: The findings indicate that HIV-2 Env is highly immunogenic in natural infection, that high-titer broadly neutralizing antibodies are commonly elicited, and that unlike HIV-1, native HIV- 2 Env trimers expose multiple broadly cross-reactive epitopes readily accessible to NAbs.
Journal ArticleDOI
Determinants of human immunodeficiency virus type 1 baseline susceptibility to the fusion inhibitors enfuvirtide and T-649 reside outside the peptide interaction site.
Marintha L. Heil,Julie M. Decker,Jeffrey N. Sfakianos,George M. Shaw,George M. Shaw,Eric Hunter,Cynthia A. Derdeyn +6 more
TL;DR: It is hypothesized that both gp120 gene- and gp41 gene-encoded determinants that minimize the window of opportunity for PFI to bind provide a growth advantage and possibly a predisposition to resistance to this new class of drugs in vivo.
Journal ArticleDOI
Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome
Hongshuo Song,Jeffrey W. Pavlicek,Fangping Cai,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Hui Li,Shilpa S. Iyer,Katharine J. Bar,Julie M. Decker,Nilu Goonetilleke,Michael K. P. Liu,Anna Berg,Bhavna Hora,Mark S. Drinker,Josh A Eudailey,Joy Pickeral,M. Anthony Moody,Guido Ferrari,Andrew J. McMichael,Alan S. Perelson,George M. Shaw,Beatrice H. Hahn,Barton F. Haynes,Feng Gao +23 more
TL;DR: A broad spectrum of fitness costs to CTL escape mutations in T/F viral genomes are revealed, similar to recent findings reported for neutralizing antibody escape mutations, and highlight the extraordinary plasticity and adaptive potential of the HIV-1 genome.