R
Rui Kong
Researcher at National Institutes of Health
Publications - 28
Citations - 3308
Rui Kong is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Epitope & HIV vaccine. The author has an hindex of 20, co-authored 28 publications receiving 2703 citations. Previous affiliations of Rui Kong include University of Alabama at Birmingham & University of Pennsylvania.
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Journal ArticleDOI
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nicole A. Doria-Rose,Chaim A. Schramm,Jason Gorman,Penny L. Moore,Jinal N. Bhiman,Brandon J. DeKosky,Michael J. Ernandes,Ivelin S. Georgiev,Helen J. Kim,Marie Pancera,Ryan P. Staupe,Han Altae-Tran,Robert T. Bailer,Ema T. Crooks,Albert Cupo,Aliaksandr Druz,Nigel Garrett,Kam Hon Hoi,Rui Kong,Mark K. Louder,Nancy S. Longo,Krisha McKee,Molati Nonyane,Sijy O'Dell,Ryan S. Roark,Rebecca S. Rudicell,Stephen D. Schmidt,Daniel J. Sheward,Cinque Soto,Constantinos Kurt Wibmer,Yongping Yang,Zhenhai Zhang,Nisc Comparative Sequencing,James C. Mullikin,James M. Binley,Rogier W. Sanders,Ian A. Wilson,John P. Moore,Andrew B. Ward,George Georgiou,Carolyn Williamson,Salim S. Abdool Karim,Lynn Morris,Peter D. Kwong,Lawrence Shapiro,John R. Mascola +45 more
TL;DR: HIV-1 V1V2-directed neutralizing antibodies can develop relatively rapidly through initial selection of B cells with a long CDR H3, and limited subsequent somatic hypermutation, and provide important insights relevant to HIV-1 vaccine development.
Journal ArticleDOI
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Guillaume Stewart-Jones,Cinque Soto,Thomas Lemmin,Thomas Lemmin,Gwo-Yu Chuang,Aliaksandr Druz,Rui Kong,Paul V. Thomas,Kshitij Wagh,Tongqing Zhou,Anna-Janina Behrens,Tatsiana Bylund,Chang W. Choi,Jack R. Davison,Ivelin S. Georgiev,M. Gordon Joyce,Young Do Kwon,Marie Pancera,Justin Taft,Yongping Yang,Baoshan Zhang,Sachin S. Shivatare,Vidya S. Shivatare,Chang-Chun D Lee,Chung-Yi Wu,Carole A. Bewley,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Mark Connors,Max Crispin,Ulrich Baxa,Bette T. Korber,Chi-Huey Wong,Chi-Huey Wong,John R. Mascola,Peter D. Kwong +36 more
TL;DR: Crystallized fully glycosylated Env trimers from clades A, B, and G reveal a diversity in oligosaccharide affinity and a requirement for accommodating glycans among known broadly neutralizing antibodies that target the glycan-shielded trimer.
Journal ArticleDOI
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
Rui Kong,Kai Xu,Tongqing Zhou,Priyamvada Acharya,Thomas Lemmin,Kevin Liu,Gabriel Ozorowski,Gabriel Ozorowski,Cinque Soto,Justin Taft,Robert T. Bailer,Evan M. Cale,Lei Chen,Chang W. Choi,Gwo-Yu Chuang,Nicole A. Doria-Rose,Aliaksandr Druz,Ivelin S. Georgiev,Jason Gorman,Jinghe Huang,M. Gordon Joyce,Mark K. Louder,Xiaochu Ma,Krisha McKee,Sijy O'Dell,Marie Pancera,Yongping Yang,Scott C. Blanchard,Walther Mothes,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Mark Connors,Andrew B. Ward,Andrew B. Ward,Peter D. Kwong,John R. Mascola +36 more
TL;DR: The identification of a neutralizing antibody, N123-VRC34.01, which targets the fusion peptide and blocks viral entry by inhibiting conformational changes in gp120 and gp41 subunits of Env required for entry.
Journal ArticleDOI
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Mattia Bonsignori,Tongqing Zhou,Zizhang Sheng,Lei Chen,Feng Gao,M. Gordon Joyce,Gabriel Ozorowski,Gwo-Yu Chuang,Chaim A. Schramm,Kevin Wiehe,S. Munir Alam,Todd Bradley,Morgan A. Gladden,Kwan-Ki Hwang,Sheelah Iyengar,Amit Kumar,Xiaozhi Lu,Kan Luo,Michael C. Mangiapani,Robert Parks,Hongshuo Song,Priyamvada Acharya,Robert T. Bailer,Allen Cao,Aliaksandr Druz,Ivelin S. Georgiev,Young Do Kwon,Mark K. Louder,Baoshan Zhang,Anqi Zheng,Brenna J. Hill,Rui Kong,Cinque Soto,James C. Mullikin,Daniel C. Douek,David C. Montefiori,M. A. Moody,George M. Shaw,Beatrice H. Hahn,Garnett Kelsoe,Peter T. Hraber,Bette T. Korber,Scott D. Boyd,Andrew Fire,Thomas B. Kepler,Lawrence Shapiro,Lawrence Shapiro,Andrew B. Ward,John R. Mascola,Hua-Xin Liao,Peter D. Kwong,Barton F. Haynes +51 more
TL;DR: The development of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates is defined with longitudinal sampling from time-of-infection to suggest a vaccination strategy for inducing both lineages.
Journal ArticleDOI
Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
Tongqing Zhou,Rebecca M. Lynch,Lei Chen,Priyamvada Acharya,Xueling Wu,Nicole A. Doria-Rose,M. Gordon Joyce,Daniel Lingwood,Cinque Soto,Robert T. Bailer,Michael J. Ernandes,Rui Kong,Nancy S. Longo,Mark K. Louder,Krisha McKee,Sijy O'Dell,Stephen D. Schmidt,Lillian Tran,Zhongjia Yang,Aliaksandr Druz,Timothy S. Luongo,Stephanie Moquin,Sanjay Srivatsan,Yongping Yang,Baoshan Zhang,Anqi Zheng,Marie Pancera,Tatsiana Kirys,Ivelin S. Georgiev,Tatyana Gindin,Hung-Pin Peng,An-Suei Yang,James C. Mullikin,Matthew D. Gray,Leonidas Stamatatos,Dennis R. Burton,Dennis R. Burton,Wayne C. Koff,Myron S. Cohen,Barton F. Haynes,Joseph P. Casazza,Mark Connors,Davide Corti,Antonio Lanzavecchia,Quentin J. Sattentau,Robin A. Weiss,Anthony P. West,Pamela J. Bjorkman,Johannes F. Scheid,Michel C. Nussenzweig,Michel C. Nussenzweig,Lawrence Shapiro,Lawrence Shapiro,John R. Mascola,Peter D. Kwong +54 more
TL;DR: The repertoire for effective recognition of the CD4 supersite thus comprises antibodies with distinct paratopes arrayed about two optimal geometric orientations, one achieved by CDR H3 ontogenies and the other achieved by VH-gene-restricted ontogeny.