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Bhavna Hora
Researcher at Duke University
Publications - 29
Citations - 1101
Bhavna Hora is an academic researcher from Duke University. The author has contributed to research in topics: Viral replication & Epitope. The author has an hindex of 12, co-authored 25 publications receiving 903 citations. Previous affiliations of Bhavna Hora include Durham University.
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Journal ArticleDOI
Phenotypic properties of transmitted founder HIV-1
Nicholas F. Parrish,Feng Gao,Hui Li,Elena E. Giorgi,Hannah J. Barbian,Erica H. Parrish,Lara Zajic,Shilpa S. Iyer,Julie M. Decker,Amit Kumar,Bhavna Hora,Anna Berg,Fangping Cai,Jennifer Hopper,Thomas N. Denny,Haitao Ding,Christina Ochsenbauer,John C. Kappes,Rachel P. Galimidi,Anthony P. West,Pamela J. Bjorkman,Craig B. Wilen,Robert W. Doms,Robert W. Doms,Meagan O’Brien,Nina Bhardwaj,Persephone Borrow,Barton F. Haynes,Mark Muldoon,James Theiler,Bette T. Korber,George M. Shaw,Beatrice H. Hahn +32 more
TL;DR: TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.
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Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
Nicholas F. Parrish,Craig B. Wilen,Lauren B. Banks,Shilpa S. Iyer,Jennifer M. Pfaff,Jesus F. Salazar-Gonzalez,Maria G. Salazar,Julie M. Decker,Erica H. Parrish,Anna Berg,Jennifer Hopper,Bhavna Hora,Amit Kumar,Tatenda Mahlokozera,Sally Yuan,Charl Coleman,Marion Vermeulen,Haitao Ding,Christina Ochsenbauer,John C. Tilton,Sallie R. Permar,John C. Kappes,Michael R. Betts,Michael P. Busch,Feng Gao,David C. Montefiori,Barton F. Haynes,George M. Shaw,Beatrice H. Hahn,Robert W. Doms +29 more
TL;DR: It is found that T/F and chronic control Envs were indistinguishable in the efficiency with which they used CD4 and CCR5, and saturating concentrations of anti-α4β7 antibodies failed to inhibit infection and replication of T/f as well as chronic control viruses.
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Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.
Hongshuo Song,Elena E. Giorgi,Vitaly V. Ganusov,Fangping Cai,Gayathri Athreya,Hyejin Yoon,Oana Carja,Bhavna Hora,Peter T. Hraber,Ethan Romero-Severson,Chunlai Jiang,Chunlai Jiang,Xiaojun Li,Shuyi Wang,Hui Li,Jesus F. Salazar-Gonzalez,Maria G. Salazar,Nilu Goonetilleke,Brandon F. Keele,David C. Montefiori,Myron S. Cohen,George M. Shaw,Beatrice H. Hahn,Andrew J. McMichael,Barton F. Haynes,Bette T. Korber,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Feng Gao,Feng Gao +29 more
TL;DR: A computational tool is developed to track recombination in patients, identify recombination hot spots, and show contribution of recombination to antibody escape, which provides insight into molecular mechanisms by which viral recombination contributes to HIV-1 persistence and immunopathogenesis.
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Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses
M. Anthony Moody,Feng Gao,Thaddeus C. Gurley,Joshua D. Amos,Amit Kumar,Bhavna Hora,Dawn J. Marshall,John F. Whitesides,Shi-Mao Xia,Robert Parks,Krissey E. Lloyd,Kwan-Ki Hwang,Xiaozhi Lu,Mattia Bonsignori,Andrés Finzi,Nathan Vandergrift,S. Munir Alam,Guido Ferrari,Xiaoying Shen,Georgia D. Tomaras,Gift Kamanga,Myron S. Cohen,Noel E. Sam,Saidi Kapiga,Elin S. Gray,Nancy Tumba,Lynn Morris,Susan Zolla-Pazner,Susan Zolla-Pazner,Miroslaw K. Gorny,John R. Mascola,Beatrice H. Hahn,George M. Shaw,Joseph Sodroski,Hua-Xin Liao,David C. Montefiori,Peter T. Hraber,Bette T. Korber,Barton F. Haynes +38 more
TL;DR: A role for V3 and CD4bs antibodies in constraining the native envelope trimer in vivo to aneutralization-resistant phenotype is demonstrated, explaining why HIV-1 transmission generally occurs by tier 2 neutralization- resistant viruses.
Journal ArticleDOI
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses
Todd Bradley,Dimitra Peppa,Isabela Pedroza-Pacheco,Dapeng Li,Derek W. Cain,Ricardo Henao,Vaishnavi Venkat,Bhavna Hora,Yue Chen,Nathan Vandergrift,R. Glenn Overman,R. Whitney Edwards,Christopher W. Woods,Christopher W. Woods,Georgia D. Tomaras,Guido Ferrari,Geoffrey S. Ginsburg,Geoffrey S. Ginsburg,Mark Connors,Myron S. Cohen,M. Anthony Moody,Persephone Borrow,Barton F. Haynes +22 more
TL;DR: The data suggest that NK cells and Rab11 recycling endosomal transport are involved in regulation of HIV-1 bnAb development, and that RAB11FIP5 overexpression modulated the function of NK cells.