J
Julie P.I. Welburn
Researcher at University of Edinburgh
Publications - 41
Citations - 2521
Julie P.I. Welburn is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Microtubule & Mitosis. The author has an hindex of 19, co-authored 34 publications receiving 2185 citations. Previous affiliations of Julie P.I. Welburn include AstraZeneca & University of Oxford.
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Journal ArticleDOI
Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface
Julie P.I. Welburn,Mathijs Vleugel,Dan Liu,John R. Yates,Michael A. Lampson,Tatsuo Fukagawa,Iain M. Cheeseman +6 more
TL;DR: In this article, the authors demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/Ndc80 complex (KMN) network.
Journal ArticleDOI
CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.
Tetsuya Hori,Miho Amano,Aussie Suzuki,Chelsea B. Backer,Julie P.I. Welburn,Yimin Dong,Bruce F. McEwen,Wei-Hao Shang,Emiko Suzuki,Katsuya Okawa,Iain M. Cheeseman,Tatsuo Fukagawa +11 more
TL;DR: This work identifies CENP-W as a component of the DNA-proximal constitutive centromere-associated network (CCAN) of proteins and demonstrates that CENp-W forms a DNA-binding complex together with the CCAN component C ENP-T.
Journal ArticleDOI
The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility.
Julie P.I. Welburn,Ekaterina L. Grishchuk,Chelsea B. Backer,Elizabeth M. Wilson-Kubalek,John R. Yates,Iain M. Cheeseman +5 more
TL;DR: A critical role for the Ska1 complex in interacting with dynamic microtubules at the outer kinetochore is demonstrated and two separable biochemical activities are demonstrated: direct microtubule binding through theSka1 subunit, and microtubul-stimulated oligomerization imparted by the Rama1 sub unit.
Journal ArticleDOI
Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3
Neil Macdonald,Julie P.I. Welburn,Martin E.M. Noble,Anhco Nguyen,Michael B. Yaffe,David Clynes,Jonathan G. Moggs,George Orphanides,Stuart Thomson,John W. Edmunds,Alison L. Clayton,Jane A. Endicott,Louis C. Mahadevan +12 more
TL;DR: The structures of 14-3-3zeta complexed with serine 10-phosphorylated or phosphoacetylated H3 peptides are determined, revealing a distinct mode of 14,3,3/phosphopeptide binding and providing a structural understanding for the lack of effect of acetylation at lysines 9 and 14 on this interaction.
Journal ArticleDOI
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
Janko Kajtez,Anastasia Solomatina,Maja Novak,Bruno Polak,Kruno Vukušić,Jonas Rudiger,Gheorge Cojoc,Ana Milas,Ivana Šumanovac Šestak,Patrik Risteski,Federica Tavano,Anna H. Klemm,Emanuele Roscioli,Emanuele Roscioli,Emanuele Roscioli,Julie P.I. Welburn,Daniela Cimini,Daniela Cimini,Matko Glunčić,Nenad Pavin,Iva M. Tolić +20 more
TL;DR: It is concluded that the bridging fibre, by linking sister k-fibres, withstands the tension between sister kinetochores and enables the spindle to obtain a curved shape.