J
Jun Ooehara
Researcher at University of Tokyo
Publications - 9
Citations - 1162
Jun Ooehara is an academic researcher from University of Tokyo. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 7, co-authored 9 publications receiving 1000 citations.
Papers
More filters
Journal ArticleDOI
Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells
Ryo Yamamoto,Yohei Morita,Jun Ooehara,Sanae Hamanaka,Masafumi Onodera,Karl Lenhard Rudolph,Hideo Ema,Hiromitsu Nakauchi +7 more
TL;DR: The results show that loss of self-renewal and stepwise progression through specific differentiation stages are not essential for lineage commitment of HSCs and suggest a revised model of hematopoietic differentiation.
Journal ArticleDOI
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.
Jun Seita,Hideo Ema,Jun Ooehara,Satoshi Yamazaki,Yuko Tadokoro,Akiko Yamasaki,Koji Eto,Satoshi Takaki,Kiyoshi Takatsu,Hiromitsu Nakauchi +9 more
TL;DR: It is shown that Lnk negatively regulates self-renewal of HSCs by modifying thrombopoietin (TPO)-mediated signal transduction, and suggests that a balance in positive and negative signals downstream from the TPO signal plays a role in the regulation of the probability of self-Renewal in H SCs.
Journal ArticleDOI
VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment
Masato Murakami,Yujuan Zheng,Masanori Hirashima,Toshio Suda,Yohei Morita,Jun Ooehara,Hideo Ema,Guo-Hua Fong,Masabumi Shibuya,Masabumi Shibuya +9 more
TL;DR: The recruitment of VEGFR1-expressing macrophages driven by VEGF-A was reduced in K14 Vegf-A Tg Vegfr1 tk−/− mice and the mechanism underlying the decrease in lymphangiogensis was investigated.
Journal ArticleDOI
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment
Ryo Yamamoto,Adam C. Wilkinson,Jun Ooehara,Xun Lan,Chen-Yi Lai,Yusuke Nakauchi,Jonathan K. Pritchard,Hiromitsu Nakauchi,Hiromitsu Nakauchi +8 more
TL;DR: The results question the traditional dogma of HSC aging and the current approaches to assay and define HSCs.
Journal ArticleDOI
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Jun Seita,Masayuki Asakawa,Jun Ooehara,Shin-ichiro Takayanagi,Yohei Morita,Nobukazu Watanabe,Koji Fujita,Motoshige Kudo,Junichiro Mizuguchi,Hideo Ema,Hiromitsu Nakauchi,Takayuki Yoshimoto +11 more
TL;DR: It is shown that IL-27 together with stem cell factor (SCF) directly acts on HSCs and supports their early differentiation in vitro and in vivo, and suggests thatIL-27 is one of the limited cytokines that play a role in HSC regulation.