J
Justin W. Davis
Researcher at AbbVie
Publications - 25
Citations - 443
Justin W. Davis is an academic researcher from AbbVie. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 9, co-authored 22 publications receiving 221 citations.
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Journal ArticleDOI
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Jack A. Kosmicki,Julie E. Horowitz,Nilanjana Banerjee,Rouel Lanche,Anthony Marcketta,Evan Maxwell,Xiaodong Bai,Dylan Sun,Joshua D. Backman,Deepika Sharma,F. S. P. Kury,Hyun Min Kang,Colm O'Dushlaine,Ashish Yadav,Adam J. Mansfield,Alexander H. Li,Kyoko Watanabe,Lauren Gurski,Shane McCarthy,Adam E. Locke,Shareef Khalid,Sean O'Keeffe,Joelle Mbatchou,Olympe Chazara,Yunfeng Huang,Erika Kvikstad,A. O'Neill,Paul Nioi,Margaret M. Parker,Slavé Petrovski,Heiko Runz,Joseph D. Szustakowski,Quanli Wang,Emily Wong,A. Cordova-Palomera,E. N. Smith,Sándor Szalma,Xiuwen Zheng,Sahar Esmaeeli,Justin W. Davis,Yi-Pin Lai,Xing Chen,Anne E. Justice,Joseph B. Leader,Tooraj Mirshahi,David J. Carey,Anurag Verma,Giorgio Sirugo,Marylyn D. Ritchie,Daniel J. Rader,Gundula Povysil,David Goldstein,Krzysztof Kiryluk,Erola Pairo-Castineira,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Alison M. Meynert,Athanasios Kousathanas,Loukas Moutsianas,Albert Tenesa,Mark J. Caulfield,Richard H Scott,James F. Wilson,J. K. Baillie,Guillaume Butler-Laporte,Tomoko Nakanishi,Mark Lathrop,J. B. Richards,Martin I. Jones,Suganthi Balasubramanian,Will Salerno,A. R. Shuldiner,Jonathan Marchini,John D. Overton,Lukas Habegger,Michael N. Cantor,Jeffrey G. Reid,A. Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira +80 more
TL;DR: In this article, the authors used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a respiratory illness causing hospitalization or death.
Journal ArticleDOI
Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease
Aparna Vasanthakumar,Justin W. Davis,Kenneth B. Idler,Jeffrey F. Waring,Elizabeth Asque,Bridget Riley-Gillis,Shaun Grosskurth,Gyan Srivastava,Sungeun Kim,Sungeun Kim,Kwangsik Nho,Kelly N.H. Nudelman,Kelley Faber,Yu Sun,Tatiana Foroud,Karol Estrada,Liana G. Apostolova,Qingqin S. Li,Andrew J. Saykin +18 more
TL;DR: Cross-diagnosis differential peripheral DNA methylation between age-matched subjects with AD relative to healthy controls will provide opportunities to further investigate and validate differential methylation as a surrogate of disease.
Journal ArticleDOI
Identification of HLA-DRB1 association to adalimumab immunogenicity.
Mohan Liu,Jacob F. Degner,Justin W. Davis,Kenneth B. Idler,Ahmed Nader,Nael M. Mostafa,Jeffrey F. Waring +6 more
TL;DR: Using next-generation sequencing-based HLA typing, it is suggested that specific HLA alleles may play a key role in developing AAAs in RA and HS patients treated with adalimumab.
Journal ArticleDOI
Psoriatic skin molecular and histopathologic profiles after treatment with risankizumab versus ustekinumab
Sudha Visvanathan,Patrick Baum,Richard Vinisko,Ramona Schmid,Mary Flack,Bojan Lalovic,Oliver Kleiner,Judilyn Fuentes-Duculan,Sandra Garcet,Justin W. Davis,Kristie M. Grebe,Jay S. Fine,Steven J. Padula,James G. Krueger +13 more
TL;DR: Risankizumab more strongly downregulated expression of genes associated with keratinocytes, epidermal cells, and monocytes, versus ustekinumab, and demonstrated more pronounced changes in the molecular and histopathologic profile of psoriatic skin lesions at week 4.
Journal ArticleDOI
Genetic analysis of NCSTN for potential association with hidradenitis suppurativa in familial and nonfamilial patients.
TL;DR: This is the first study to report this mutation in a white subject with a family history of HS, and the allelic odds ratio (OR) was computed, as well as other models of genetic association (dominant, recessive, co-dominant and overdominant) stratified by ethnicity.