Olympe Chazara

TL;DR: In this article, the authors used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a respiratory illness causing hospitalization or death.

TL;DR: The authors' analyses corroborate the association with the 3p21.31 locus and highlight that there are no rare protein-coding variant associations with effect sizes detectable at current sample sizes, as well as identifying two loci associated with risk of infection at P<5x10-8.

TL;DR: An increased burden of diagnostic mendelian cardiomyopathy variants in a broad group of patients with HF of mostly ischemic etiology compared with controls was observed, providing further evidence that mendelia genetic conditions may represent an important subset of complex late-onset diseases such as HF, irrespective of the clinical presentation.

TL;DR: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure as mentioned in this paper, which includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls.

TL;DR: In this paper, the authors conducted a pharmacogenomic study of the CHARM studies to identify genetic predictors of heart failure progression and the efficacy and safety of treatment with candesartan, and found the genetic variant rs66886237 at 8p21.3 near the gene GFRA2 to be associated with the composite cardiovascular endpoint in 2727 patients from CHARM-Overall and stratified by CHARM study.