J
Justo Cobo
Researcher at University of Jaén
Publications - 492
Citations - 3545
Justo Cobo is an academic researcher from University of Jaén. The author has contributed to research in topics: Hydrogen bond & Molecule. The author has an hindex of 26, co-authored 484 publications receiving 3148 citations.
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Journal ArticleDOI
Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents
Braulio Insuasty,Alexis Tigreros,Fabian Orozco,Jairo Quiroga,Rodrigo Abonia,Manuel Nogueras,Adolfo Sánchez,Justo Cobo +7 more
TL;DR: Several novel compounds synthesized from a Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives were screened by the US National Cancer Institute for their ability to inhibit 60 different human tumor cell lines.
Journal ArticleDOI
Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity.
Rodrigo Abonia,Daniel Insuasty,Juan C. Castillo,Braulio Insuasty,Jairo Quiroga,Manuel Nogueras,Justo Cobo +6 more
TL;DR: Novel quinoline-2-one based chalcones were synthesized from a Claisen-Schmidt condensation by using the couple KOH/1,4-dioxane as reaction medium and may possibly be used as lead compound for developing new anticancer agents.
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Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.
Braulio Insuasty,Alba Montoya,Diana Becerra,Jairo Quiroga,Rodrigo Abonia,Sara M. Robledo,Iván D. Vélez,Yulieth Upegui,Manuel Nogueras,Justo Cobo +9 more
TL;DR: A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7-8 showed remarkable antitumor activity against cancer cell lines, with the most important GI50 values ranging from 0.13 to 0.99 μM.
Journal ArticleDOI
Regioselective synthesis of 4,7,8,9-tetrahydro-2 H -pyrazolo[3,4- b ]quinolin-5(6 H )-ones. Mechanism and structural analysis
Jairo Quiroga,Diana Mejía,Braulio Insuasty,Rodrigo Abonia,Manuel Nogueras,Adolfo Sánchez,Justo Cobo,John N. Low +7 more
TL;DR: In this paper, a tricyclic linear 3,7,7-trimethyl-4, 7, 8, 9-tetrahydro-2H-pyrazolo[3,4-b]quinolin-5(6H)-one with dimedone and aldehydes was obtained.
Journal ArticleDOI
Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents.
TL;DR: Novel methyl 1-tert-butyl-1-pyrazol-3-yl)-2-(aryl)-1H-benzo[d]imidazole-5-carboxylates 11 were synthesized by following a four-step strategy involving a nucleophilic aromatic displacement (S(N)Ar) and a solvent free approach as key steps for the formation of the desired products.