K
Kanneboyina Nagaraju
Researcher at Binghamton University
Publications - 189
Citations - 9970
Kanneboyina Nagaraju is an academic researcher from Binghamton University. The author has contributed to research in topics: Duchenne muscular dystrophy & Skeletal muscle. The author has an hindex of 52, co-authored 181 publications receiving 8793 citations. Previous affiliations of Kanneboyina Nagaraju include Children's National Medical Center & Johns Hopkins University.
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Journal ArticleDOI
Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy
Livia Casciola-Rosen,Kanneboyina Nagaraju,Paul H. Plotz,Kondi Wang,Stuart M. Levine,Edward Gabrielson,Andrea M. Corse,Antony Rosen +7 more
TL;DR: It is proposed that in cancer-associated myositis, an autoimmune response directed against cancer cross-reacts with regenerating muscle cells, enabling a feed-forward loop of tissue damage and antigen selection and Regulating pathways of antigen expression may provide unrecognized therapeutic opportunities in autoimmune diseases.
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Activation of the endoplasmic reticulum stress response in autoimmune myositis: Potential role in muscle fiber damage and dysfunction
Kanneboyina Nagaraju,Livia Casciola-Rosen,Ingrid E. Lundberg,Rashmi Rawat,Shawna Cutting,Rachana Thapliyal,Jason Chang,Sunita Dwivedi,Megan Mitsak,Yi-Wen Chen,Paul H. Plotz,Antony Rosen,Eric P. Hoffman,Nina Raben +13 more
TL;DR: Investigating the pathways of endoplasmic reticulum stress response, the unfolded protein response, and the ER overload response in muscle tissue of human myositis patients and in the mouse model indicates that the ER stress response may be a major nonimmune mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositIS.
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Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
TL;DR: A wide range of techniques used to measure parameters of muscle pathology in mdx mice are described and some basic techniques that might comprise standardised approaches for evaluation are identified.
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Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies.
Kanneboyina Nagaraju,Nina Raben,Lisa Loeffler,Tomasina Parker,Paul J. Rochon,Eunice Lee,Carol L. Danning,Ryuichi Wada,Cynthia D. Thompson,Gul Bahtiyar,Joe Craft,Rob Hooft van Huijsduijnen,Paul H. Plotz +12 more
TL;DR: It is suggested that an autoimmune disease may unfold in a highly specific pattern as the consequence of an apparently nonspecific event-the sustained up-regulation of MHC class I in a tissue-and that the specificity of the autoantibodies derives not from the specificityOf the stimulus, but from the context, location, and probably the duration of the stimulus.
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Histidyl–tRNA Synthetase and Asparaginyl–tRNA Synthetase, Autoantigens in Myositis, Activate Chemokine Receptors on T Lymphocytes and Immature Dendritic Cells
O. M. Zack Howard,Hui Fang Dong,De Yang,Nina Raben,Kanneboyina Nagaraju,Antony Rosen,Livia Casciola-Rosen,Michael Härtlein,Michael A. Kron,David C.H. Yang,Kwabena P.A.B. Yiadom,Sunita Dwivedi,Paul H. Plotz,Joost J. Oppenheim +13 more
TL;DR: Autoantigenic aminoacyl–tRNA synthetases, perhaps liberated from damaged muscle cells, may perpetuate the development of myositis by recruiting mononuclear cells that induce innate and adaptive immune responses.