Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
TLDR
A wide range of techniques used to measure parameters of muscle pathology in mdx mice are described and some basic techniques that might comprise standardised approaches for evaluation are identified.About:
This article is published in Neurobiology of Disease.The article was published on 2008-07-01 and is currently open access. It has received 301 citations till now. The article focuses on the topics: mdx mouse & Duchenne muscular dystrophy.read more
Citations
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Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments
Valerie C. Henderson,Jonathan Kimmelman,Dean Fergusson,Dean Fergusson,Jeremy M. Grimshaw,Jeremy M. Grimshaw,Daniel G. Hackam +6 more
TL;DR: A systematic review of preclinical research guidelines and organized recommendations according to the type of validity threat (internal, construct, or external) or programmatic research activity they primarily address provided a starting point for developing preclinical guidelines in other disease domains.
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Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.
Amelia E. Hochreiter-Hufford,Chang Sup Lee,Jason M. Kinchen,Jennifer D. Sokolowski,Sanja Arandjelovic,Jarrod A. Call,Alexander L. Klibanov,Zhen-Yu Yan,James Mandell,Kodi S. Ravichandran +9 more
TL;DR: Data are identified to identify apoptotic cells as a new type of cue that induces signalling via the phosphatidylserine receptor BAI1 to promote fusion of healthy myoblasts, with important implications for muscle development and repair.
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Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle
Aurélie Chiche,Aurélie Chiche,Isabelle Roux,Mathieu von Joest,Mathieu von Joest,Hiroshi Sakai,Hiroshi Sakai,Sabela Búa Aguín,Sabela Búa Aguín,Coralie Cazin,Coralie Cazin,Rana Salam,Laurence Fiette,Olinda Alegria,Olinda Alegria,Patricia Flamant,Shahragim Tajbakhsh,Shahragim Tajbakhsh,Han Li,Han Li +19 more
TL;DR: It is shown that acute and chronic injury enables transcription-factor-mediated reprogramming in skeletal muscle and this response frequently originates from Pax7+ muscle stem cells, highlighting a beneficial paracrine effect of injury-induced senescence on cellular plasticity.
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Mammalian animal models for Duchenne muscular dystrophy
TL;DR: The currently used mammalian animal models for DMD are compared with the aim of selecting and recommending the most appropriate ones for preclinical efficacy testing of new therapeutic strategies.
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Taurine: the appeal of a safe amino acid for skeletal muscle disorders
TL;DR: Taurine treatment can be beneficial to reduce sarcolemmal hyper-excitability in myotonia-related syndromes and may represent a guide-line for designing specific studies in patients of neuromuscular diseases.
References
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