A
Andrew McCaskie
Researcher at University of Cambridge
Publications - 129
Citations - 3929
Andrew McCaskie is an academic researcher from University of Cambridge. The author has contributed to research in topics: Arthroplasty & Osteoarthritis. The author has an hindex of 30, co-authored 124 publications receiving 3386 citations. Previous affiliations of Andrew McCaskie include Freeman Hospital & Durham University.
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Journal ArticleDOI
Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study
Eleftheria Zeggini,Kalliope Panoutsopoulou,Lorraine Southam,Lorraine Southam,N W Rayner,Aaron G. Day-Williams,M C Lopes,M C Lopes,Vesna Boraska,Tõnu Esko,Evangelos Evangelou,A Hoffman,Jeanine J. Houwing-Duistermaat,Thorvaldur Ingvarsson,Ingileif Jonsdottir,Ingileif Jonsdottir,H Jonnson,Hanneke J. M. Kerkhof,Margreet Kloppenburg,Steffan D. Bos,Massimo Mangino,Sarah Metrustry,P E Slagboom,Gudmar Thorleifsson,Raine Eva.,Madhushika Ratnayake,Michelle Ricketts,C Beazley,Hannah Blackburn,Suzannah Bumpstead,K S Elliott,Sarah E. Hunt,Simon C. Potter,Shin S-Y.,Vijay K. Yadav,Guangju Zhai,K Sherburn,K Dixon,E Arden,N Aslam,Battley P-K.,I Carluke,Sally Doherty,Allan Gordon,J Joseph,Richard Keen,N Koller,Sheryl Mitchell,F O'Neill,E Paling,Mike R. Reed,Fernando Rivadeneira,D Swift,K Walker,Bridget Watkins,M. Wheeler,Fraser Birrell,Ioannidis Jpa.,Ingrid Meulenbelt,Andres Metspalu,Ashok Rai,Donald Salter,K. Stefansson,U Stykarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Karen E. Chapman,Panagiotis Deloukas,Ollier Wer.,Gillian A. Wallis,Nigel K Arden,Andrew Carr,Michael Doherty,Andrew McCaskie,J M Willkinson,Stuart Ralston,Ana M. Valdes,Tim D. Spector,John Loughlin +78 more
TL;DR: One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight—a strong risk factor for osteoarthritis.
Journal ArticleDOI
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis
Eleni Zengini,Konstantinos Hatzikotoulas,Ioanna Tachmazidou,Julia Steinberg,Julia Steinberg,Fernando Pires Hartwig,Fernando Pires Hartwig,Lorraine Southam,Lorraine Southam,Sophie Hackinger,Cindy G. Boer,Unnur Styrkarsdottir,Arthur Gilly,Daniel Suveges,Britt Kilian,Thorvaldur Ingvarsson,Thorvaldur Ingvarsson,Helgi Jonsson,George C. Babis,Andrew McCaskie,André G. Uitterlinden,Joyce B. J. van Meurs,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,George Davey Smith,George Davey Smith,Jeremy Mark Wilkinson,Eleftheria Zeggini +29 more
TL;DR: A genome-wide association study using data from UK Biobank identifies loci for knee- and hip-specific disease and establishes causal effects on osteoarthritis for higher body mass index but not for triglyceride levels or genetic predisposition to type 2 diabetes.
Journal ArticleDOI
Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial.
Antony Palmer,Vandana Ayyar Gupta,Scott Fernquest,Ines Rombach,Susan J Dutton,Ramy Mansour,Simon M. Wood,Vikas Khanduja,T. C. B. Pollard,Andrew McCaskie,Karen Barker,Tony Andrade,Andrew Carr,David J Beard,David J Beard,Sion Glyn-Jones +15 more
TL;DR: Patients with symptomatic FAI referred to secondary or tertiary care achieve superior outcomes with arthroscopic hip surgery than with physiotherapy and activity modification, according to the primary outcome measure.
Journal ArticleDOI
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22
Evangelos Evangelou,Ana M. Valdes,Hanneke J. M. Kerkhof,Unnur Styrkarsdottir,Yanyan Zhu,Ingrid Meulenbelt,Rik Lories,Fotini B. Karassa,Przemko Tylzanowski,Steffan D. Bos,Toru Akune,Nigel K Arden,Andrew Carr,Kay Chapman,L. Adrienne Cupples,Jin Dai,Panos Deloukas,Michael Doherty,Sally A Doherty,Gunnar Engström,Antonio Gonzalez,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Christina L. Hammond,Deborah J. Hart,Hafdis T. Helgadottir,Albert Hofman,Shiro Ikegawa,Thorvaldur Ingvarsson,Qing Jiang,Helgi Jonsson,Jaakko Kaprio,Hiroshi Kawaguchi,Kalle Kisand,Margreet Kloppenburg,Urho M. Kujala,L Stefan Lohmander,John Loughlin,Frank P. Luyten,Akihiko Mabuchi,Andrew McCaskie,Andrew McCaskie,Masahiro Nakajima,Peter M. Nilsson,Nao Nishida,William Ollier,Kalliope Panoutsopoulou,Tom Van de Putte,Stuart H. Ralston,F. Rivadeneira,Janna Saarela,Stefan Schulte-Merker,Dongquan Shi,P. Eline Slagboom,Akihiro Sudo,Agu Tamm,Ann Tamm,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Aspasia Tsezou,Gillian A. Wallis,J. Mark Wilkinson,Noriko Yoshimura,Eleftheria Zeggini,Eleftheria Zeggini,Guangju Zhai,Feng Zhang,Ingileif Jonsdottir,Ingileif Jonsdottir,André G. Uitterlinden,David T. Felson,Joyce B. J. van Meurs,Kari Stefansson,Kari Stefansson,John P. A. Ioannidis,Tim D. Spector +76 more
TL;DR: In this paper, a meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations.
Journal ArticleDOI
A variant in MCF2L is associated with osteoarthritis.
Aaron G. Day-Williams,Lorraine Southam,Lorraine Southam,Kalliope Panoutsopoulou,Nigel W. Rayner,Tõnu Esko,Karol Estrada,Hafdis T. Helgadottir,Albert Hofman,Thorvaldur Ingvarsson,Thorvaldur Ingvarsson,Hakon Jonsson,Aime Keis,Kerkhof Hjm.,Gudmar Thorleifsson,Nigel K Arden,Nigel K Arden,Andrew Carr,Kay Chapman,Panagiotis Deloukas,John Loughlin,Andrew McCaskie,Andrew McCaskie,Ollier Wer.,Stuart H. Ralston,Tim D. Spector,Gillian A. Wallis,Jeremy Mark Wilkinson,Jeremy Mark Wilkinson,N Aslam,F Birell,F Birell,I Carluke,J Joseph,Ashok Rai,Mike R. Reed,K Walker,Sally Doherty,Ingileif Jonsdottir,Ingileif Jonsdottir,Rose A. Maciewicz,Kenneth Muir,Andres Metspalu,Fernando Rivadeneira,Kari Stefansson,Kari Stefansson,Unnur Styrkarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Weiya Zhang,Ana M. Valdes,Michael Doherty,Eleftheria Zeggini +52 more
TL;DR: Through large-scale replication, a robust association with SNPs in MCF2L is established, and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee OA patients.