S
Steffan D. Bos
Researcher at Oslo University Hospital
Publications - 60
Citations - 3378
Steffan D. Bos is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Multiple sclerosis & Genome-wide association study. The author has an hindex of 27, co-authored 55 publications receiving 2948 citations. Previous affiliations of Steffan D. Bos include Leiden University Medical Center & Loyola University Medical Center.
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Journal ArticleDOI
Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study
Eleftheria Zeggini,Kalliope Panoutsopoulou,Lorraine Southam,Lorraine Southam,N W Rayner,Aaron G. Day-Williams,M C Lopes,M C Lopes,Vesna Boraska,Tõnu Esko,Evangelos Evangelou,A Hoffman,Jeanine J. Houwing-Duistermaat,Thorvaldur Ingvarsson,Ingileif Jonsdottir,Ingileif Jonsdottir,H Jonnson,Hanneke J. M. Kerkhof,Margreet Kloppenburg,Steffan D. Bos,Massimo Mangino,Sarah Metrustry,P E Slagboom,Gudmar Thorleifsson,Raine Eva.,Madhushika Ratnayake,Michelle Ricketts,C Beazley,Hannah Blackburn,Suzannah Bumpstead,K S Elliott,Sarah E. Hunt,Simon C. Potter,Shin S-Y.,Vijay K. Yadav,Guangju Zhai,K Sherburn,K Dixon,E Arden,N Aslam,Battley P-K.,I Carluke,Sally Doherty,Allan Gordon,J Joseph,Richard Keen,N Koller,Sheryl Mitchell,F O'Neill,E Paling,Mike R. Reed,Fernando Rivadeneira,D Swift,K Walker,Bridget Watkins,M. Wheeler,Fraser Birrell,Ioannidis Jpa.,Ingrid Meulenbelt,Andres Metspalu,Ashok Rai,Donald Salter,K. Stefansson,U Stykarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Karen E. Chapman,Panagiotis Deloukas,Ollier Wer.,Gillian A. Wallis,Nigel K Arden,Andrew Carr,Michael Doherty,Andrew McCaskie,J M Willkinson,Stuart Ralston,Ana M. Valdes,Tim D. Spector,John Loughlin +78 more
TL;DR: One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight—a strong risk factor for osteoarthritis.
Journal ArticleDOI
Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study.
Wim G. Goettsch,Steffan D. Bos,NS Breekveldt-Postma,Mariel K. Casparie,Ron M. C. Herings,Pancras C.W. Hogendoorn +5 more
TL;DR: The reported incidence of GIST and GIST-like tumours before and after the routine availability of the specific diagnostic marker CD117 antigen was investigated and it was indicated that almost 50% of the GIST was considered to be at high-risk for malignant behaviour according to the consensus criteria.
Journal ArticleDOI
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
Roderick C. Slieker,Steffan D. Bos,Jelle J. Goeman,Judith V.M.G. Bovée,Rudolf P. Talens,Ruud van der Breggen,H. Eka D. Suchiman,Eric-Wubbo Lameijer,Hein Putter,Erik B. van den Akker,Erik B. van den Akker,Yanju Zhang,J. Wouter Jukema,P. Eline Slagboom,Ingrid Meulenbelt,Bastiaan T. Heijmans +15 more
TL;DR: The utility of creating an atlas cataloguing variably methylated regions in internal tissues that correlate to DNA methylation measured in easy accessible peripheral tissues is suggested.
Journal ArticleDOI
Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis
Ingrid Meulenbelt,Josine L. Min,Steffan D. Bos,N. Riyazi,Jeanine J. Houwing-Duistermaat,Henk-Jan van der Wijk,Herman M. Kroon,Masahiro Nakajima,Shiro Ikegawa,André G. Uitterlinden,Joyce B. J. van Meurs,Wendy M van der Deure,Theo J. Visser,Albert B. Seymour,Nico Lakenberg,Ruud van der Breggen,Dennis Kremer,Cornelia M. van Duijn,Margreet Kloppenburg,John Loughlin,P. Eline Slagboom +20 more
TL;DR: A genome-wide linkage scan and combined linkage association analysis indicated a new susceptibility gene (DIO2) conferring risk to osteoarthritis, which converts intracellular pro-hormone-3,3',5,5'-tetraiodothyronine (T4) into the active thyroid hormone 3,3,5-triiodothyrone (T3) thereby regulating intrace cellular levels of active T3 in target tissues such as the growth plate.
Journal ArticleDOI
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
Eleonora Porcu,Marco Medici,Giorgio Pistis,Claudia B. Volpato,Scott Wilson,Anne R. Cappola,Steffan D. Bos,Joris Deelen,Martin den Heijer,Rachel M. Freathy,Jari Lahti,Chunyu Liu,Lorna M. Lopez,Ilja M. Nolte,Jeffrey R. O'Connell,Toshiko Tanaka,Stella Trompet,Alice M. Arnold,Stefania Bandinelli,Marian Beekman,Stefan Böhringer,Suzanne J. Brown,Brendan M. Buckley,Clara Camaschella,Anton J. M. de Craen,Gail Davies,Marieke de Visser,Ian Ford,Tom Forsén,Timothy M. Frayling,Laura Fugazzola,Martin Gögele,Andrew T. Hattersley,Ad R. M. M. Hermus,Albert Hofman,Jeanine J. Houwing-Duistermaat,Richard A. Jensen,Eero Kajantie,Margreet Kloppenburg,Ee Mun Lim,Corrado Masciullo,Stefano Mariotti,Cosetta Minelli,Braxton D. Mitchell,Ramaiah Nagaraja,Romana T. Netea-Maier,Aarno Palotie,Luca Persani,Maria Grazia Piras,Bruce M. Psaty,Katri Räikkönen,J. Brent Richards,Fernando Rivadeneira,Cinzia Sala,Mona M. Sabra,Naveed Sattar,Beverley M. Shields,Nicole Soranzo,John M. Starr,David J. Stott,Fred C.G.J. Sweep,Gianluca Usala,Melanie M. van der Klauw,Diana van Heemst,Alies A. van Mullem,Sita H. Vermeulen,W. Edward Visser,John P. Walsh,Rudi G. J. Westendorp,Elisabeth Widen,Guangju Zhai,Francesco Cucca,Ian J. Deary,Johan G. Eriksson,Luigi Ferrucci,Caroline S. Fox,J. Wouter Jukema,Lambertus A. Kiemeney,Peter P. Pramstaller,David Schlessinger,Alan R. Shuldiner,Eline Slagboom,André G. Uitterlinden,Bijay Vaidya,Theo J. Visser,Bruce H. R. Wolffenbuttel,Ingrid Meulenbelt,Jerome I. Rotter,Tim D. Spector,Andrew A. Hicks,Daniela Toniolo,Serena Sanna,Robin P. Peeters,Silvia Naitza +93 more
TL;DR: A large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4 improves the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism.