K
Karine G. Le Roch
Researcher at University of California, Riverside
Publications - 145
Citations - 12506
Karine G. Le Roch is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 45, co-authored 127 publications receiving 11298 citations. Previous affiliations of Karine G. Le Roch include University of the South Pacific & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expression
Ferhat Ay,Evelien M. Bunnik,Nelle Varoquaux,Sebastiaan Bol,Jacques Prudhomme,Jean-Philippe Vert,William Stafford Noble,Karine G. Le Roch +7 more
TL;DR: The results are indicative of a strong association between the P. falciparum spatial genome organization and gene expression, and the molecular processes involved in genome conformation dynamics could contribute to the discovery of novel antimalarial strategies.
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A Systematic Map of Genetic Variation in Plasmodium falciparum
Claire Kidgell,Sarah K. Volkman,Johanna P. Daily,Justin O. Borevitz,David Plouffe,Yingyao Zhou,Jeffrey R. Johnson,Karine G. Le Roch,Ousmane Sarr,Omar Ndir,S. Mboup,Serge Batalov,Dyann F. Wirth,Elizabeth A. Winzeler,Elizabeth A. Winzeler +14 more
TL;DR: It is speculated that an amplification of the GTP cyclohydrolase enzyme in the folate biosynthesis pathway may increase flux through this pathway and facilitate parasite resistance to antifolate drugs.
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Recent advances in malaria drug discovery.
TL;DR: Drug discovery efforts directed towards the liver and transmission stages are in their infancy but are receiving increasing attention as targeting these stages could be instrumental in eradicating malaria.
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Marine actinomycetes: a new source of compounds against the human malaria parasite.
Jacques Prudhomme,Eric McDaniel,Nadia Ponts,Stéphane Bertani,William Fenical,Paul A. Jensen,Karine G. Le Roch +6 more
TL;DR: It is shown that salinosporamide A protected mice against deadly malaria infection when administered at an extremely low dosage, underline the potential of secondary metabolites, derived from marine microorganisms, to inhibit Plasmodium growth.
Journal ArticleDOI
A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling.
Tobili Y. Sam-Yellowe,Laurence Florens,Jeffrey R. Johnson,Tongmin Wang,Judith A. Drazba,Karine G. Le Roch,Yingyao Zhou,Serge Batalov,Daniel J. Carucci,Elizabeth A. Winzeler,John R. Yates +10 more
TL;DR: A novel subtelomeric gene family in Plasmodium falciparum that encodes 11 transmembrane proteins localized to the Maurer's clefts is identified and coimmunoprecipitation and shotgun proteomics are used to enrich specifically for these proteins and detect distinct peptides.