K
Karine G. Le Roch
Researcher at University of California, Riverside
Publications - 145
Citations - 12506
Karine G. Le Roch is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 45, co-authored 127 publications receiving 11298 citations. Previous affiliations of Karine G. Le Roch include University of the South Pacific & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Nucleosome landscape and control of transcription in the human malaria parasite
Nadia Ponts,Elena Y. Harris,Jacques Prudhomme,Ivan Wick,Colleen Eckhardt-Ludka,Glenn R. Hicks,Gary Hardiman,Stefano Lonardi,Karine G. Le Roch +8 more
TL;DR: It is postulate that chromatin structure and nucleosome turnover control massive transcription during the erythrocytic cycle of the human malaria parasite, and the results demonstrate that the processes driving gene expression in Plasmodium challenge the classical eukaryotic model of transcriptional regulation occurring mostly at the transcription initiation level.
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Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparum
Evelien M. Bunnik,Duk-Won D. Chung,Michael Hamilton,Nadia Ponts,Nadia Ponts,Anita Saraf,Jacques Prudhomme,Laurence Florens,Karine G. Le Roch +8 more
TL;DR: Different layers of translational regulation are likely to contribute to a complex network that controls gene expression in this eukaryotic pathogen, and disrupting the mechanisms involved in such translational control could provide novel anti-malarial strategies.
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Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.
Dominique Dorin,Karine G. Le Roch,Pina Sallicandro,Pietro Alano,Daniel Parzy,Patrick Poullet,Laurent Meijer,Christian Doerig +7 more
TL;DR: It is shown that recombinant Pfnek-1 can be used in inhibition assays to monitor the effect of kinase inhibitors, which opens the way to the screening of chemical libraries aimed at identifying potential new antimalarials.
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In silico discovery of transcription regulatory elements in Plasmodium falciparum
Jason A. Young,Jeffery R Johnson,Christopher Benner,S. Frank Yan,Kaisheng Chen,Karine G. Le Roch,Yingyao Zhou,Elizabeth A. Winzeler,Elizabeth A. Winzeler +8 more
TL;DR: The fact that regulatory elements were predicted from a diverse range of functional gene clusters supports the hypothesis that cis-regulatory elements play a role in the transcriptional control of many P. falciparum biological processes.
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In Vivo Transcriptome of Plasmodium falciparum Reveals Overexpression of Transcripts That Encode Surface Proteins
Johanna P. Daily,Johanna P. Daily,Karine G. Le Roch,Ousmane Sarr,Daouda Ndiaye,Amanda K. Lukens,Yingyao Zhou,Omar Ndir,S. Mboup,Ali A. Sultan,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Dyann F. Wirth +12 more
TL;DR: Comparative studies of the transcriptomes derived from in vivo samples and in vitro 3D7 samples may identify important strategies used by the pathogen for survival in the human host and highlight, for vaccine development, new candidate antigens that were not previously identified through the use of in vitro cultures.