K
Karine G. Le Roch
Researcher at University of California, Riverside
Publications - 145
Citations - 12506
Karine G. Le Roch is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 45, co-authored 127 publications receiving 11298 citations. Previous affiliations of Karine G. Le Roch include University of the South Pacific & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20‑Diisocyanoadociane
Alexander S. Karns,Bryan D. Ellis,Philipp C. Roosen,Zeinab Chahine,Karine G. Le Roch,Christopher D. Vanderwal +5 more
TL;DR: Important contributions include a solution to the problem of axial nucleophilic methylation of a late-stage cyclohexanone, and the first selective synthesis and antiplasmodial evaluation of the DICA stereoisomer with both isonitriles equatorial.
Posted ContentDOI
Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission
Mohammad Zeeshan,David J. P. Ferguson,Steven Abel,Alana Burrrell,Edward Rea,Declan Brady,Emilie Daniel,Michael J. Delves,Sue Vaughan,Anthony A. Holder,Karine G. Le Roch,Carolyn A. Moores,Rita Tewari +12 more
TL;DR: An unexpected role for kinesin-8B in parasite flagellum formation that is vital for the parasite life cycle is uncovered.
Journal ArticleDOI
Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum
Thomas Hollin,Steven Abel,Alejandra Falla,Charisse Flerida A. Pasaje,Anil Bhatia,Manhoi Hur,Jay S. Kirkwood,Anita Saraf,Jacques Prudhomme,Amancio de Souza,Laurence Florens,Jacquin C. Niles,Karine G. Le Roch +12 more
TL;DR: In this paper , the authors used inducible knockdown studies in the human malaria parasite, Plasmodium falciparum , to show that two RAP proteins, PF3D7_0105200 (Pf RAP01) and PF3d7_1470600 (Pp RAP21), are essential for parasite survival and localize to the mitochondrion.
Posted ContentDOI
Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission
Mohammad Zeeshan,Fiona Shilliday,Tianyang Liu,Steven Abel,Tobias Mourier,David J. P. Ferguson,David J. P. Ferguson,Edward Rea,Rebecca R. Stanway,Magali Roques,Desiree Williams,Emilie Daniel,Declan Brady,Anthony J. Roberts,Anthony A. Holder,Arnab Pain,Karine G. Le Roch,Carolyn A. Moores,Rita Tewari +18 more
TL;DR: The results reveal a spatio-temporal involvement of Kinesin-8X in spindle dynamics and its association with both mitotic and meiotic spindles and the putative microtubule organising centre (MTOC) of the Plasmodium life cycle.
Journal ArticleDOI
Analysis of nucleosome positioning landscapes enables gene discovery in the human malaria parasite Plasmodium falciparum
Xueqing Maggie Lu,Evelien M. Bunnik,Neeti Pokhriyal,Sara Nasseri,Stefano Lonardi,Karine G. Le Roch +5 more
TL;DR: The results clearly indicate that nucleosome positioning data contains sufficient information for novel gene discovery and could be used to characterize the transcriptome of any organism, especially when coupled with other DNA-based gene finding and experimental methods (e.g., RNA-Seq).