K
Kate L. Jeffrey
Researcher at Harvard University
Publications - 34
Citations - 4494
Kate L. Jeffrey is an academic researcher from Harvard University. The author has contributed to research in topics: Epigenetics & Innate immune system. The author has an hindex of 16, co-authored 28 publications receiving 3625 citations. Previous affiliations of Kate L. Jeffrey include Rockefeller University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Suppression of inflammation by a synthetic histone mimic
Edwige Nicodeme,Kate L. Jeffrey,Uwe Schaefer,Soren Beinke,Scott Dewell,Chun-wa Chung,Rohit Chandwani,Ivan Marazzi,Paul A. Wilson,Hervé Coste,Julia H. White,Jorge Kirilovsky,Charles M. Rice,Jose M. Lora,Rab K. Prinjha,Kevin Lee,Alexander Tarakhovsky +16 more
TL;DR: A synthetic compound (I-BET) is described that by ‘mimicking’ acetylated histones disrupts chromatin complexes responsible for the expression of key inflammatory genes in activated macrophages, and confers protection against lipopolysaccharide-induced endotoxic shock and bacteria-induced sepsis.
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Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas
Cheolho Cheong,Ines Matos,Jae-Hoon Choi,Durga Bhavani Dandamudi,Elina Shrestha,M. Paula Longhi,Kate L. Jeffrey,Robert M. Anthony,Courtney Kluger,Godwin Nchinda,Hyein Koh,Anthony Rodriguez,Juliana Idoyaga,Maggi Pack,Klara Velinzon,Chae Gyu Park,Ralph M. Steinman +16 more
TL;DR: It is shown that fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells, and the blood monocyte reservoir becomes the dominant presenting cell in response to select microbes, yielding DC- SIGN(+) cells with critical functions of DCs.
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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
TL;DR: From a drug discovery perspective, DUSP family members are promising drug targets for manipulating MAPK-dependent immune responses in a cell-type and disease-context-dependent manner, to either boost or subdueimmune responses in cancers, infectious diseases or inflammatory disorders.
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Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis
Jr-Shiuan Yang,Thomas Maurin,Nicolas Robine,Kasper D. Rasmussen,Kate L. Jeffrey,Rohit Chandwani,Eirini P. Papapetrou,Michel Sadelain,Dónal O'Carroll,Eric C. Lai +9 more
TL;DR: It is shown that maturation of miR-451, a functional miRNA that is perfectly conserved among vertebrates, is independent of Dicer, and the mir-451 backbone is amenable to reprogramming, permitting vector-driven expression of diverse functional miRNAs in the absence of Dacer.
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Suppression of the antiviral response by an influenza histone mimic
Ivan Marazzi,Jessica Sook Yuin Ho,Jaehoon Kim,Balaji Manicassamy,Scott Dewell,Randy A. Albrecht,Christopher W. Seibert,Uwe Schaefer,Kate L. Jeffrey,Rab K. Prinjha,Kevin Lee,Adolfo García-Sastre,Robert G. Roeder,Alexander Tarakhovsky +13 more
TL;DR: It is proposed that the histone mimic in NS1 enables the influenza virus to affect inducible gene expression selectively, thus contributing to suppression of the antiviral response.