J
Jessica Sook Yuin Ho
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 21
Citations - 769
Jessica Sook Yuin Ho is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 10, co-authored 17 publications receiving 519 citations. Previous affiliations of Jessica Sook Yuin Ho include Institute of Molecular and Cell Biology & Agency for Science, Technology and Research.
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Journal ArticleDOI
Suppression of the antiviral response by an influenza histone mimic
Ivan Marazzi,Jessica Sook Yuin Ho,Jaehoon Kim,Balaji Manicassamy,Scott Dewell,Randy A. Albrecht,Christopher W. Seibert,Uwe Schaefer,Kate L. Jeffrey,Rab K. Prinjha,Kevin Lee,Adolfo García-Sastre,Robert G. Roeder,Alexander Tarakhovsky +13 more
TL;DR: It is proposed that the histone mimic in NS1 enables the influenza virus to affect inducible gene expression selectively, thus contributing to suppression of the antiviral response.
Journal ArticleDOI
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.
Alex Rialdi,Laura Campisi,Nan Zhao,Arvin Cesar Lagda,Colette Pietzsch,Jessica Sook Yuin Ho,Luis Martínez-Gil,Luis Martínez-Gil,Romain Fenouil,Xiaoting Chen,Megan R. Edwards,Giorgi Metreveli,Stefan Jordan,Zuleyma Peralta,César Muñoz-Fontela,Nicole M. Bouvier,Miriam Merad,Jian Jin,Matthew T. Weirauch,Sven Heinz,Sven Heinz,Christopher Benner,Harm van Bakel,Christopher F. Basler,Adolfo García-Sastre,Alexander Bukreyev,Ivan Marazzi +26 more
TL;DR: Chemical inhibition of topoisomerase 1 (Top1), an enzyme that unwinds DNA, suppresses the expression of infection-induced genes with little to no effect on housekeeping gene expression and without cellular damage, is found.
Journal ArticleDOI
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Jessica Sook Yuin Ho,Bobo Wing-Yee Mok,Laura Campisi,Tristan X. Jordan,Soner Yildiz,Sreeja Parameswaran,Joseph A. Wayman,Joseph A. Wayman,Natasha N. Gaudreault,David A. Meekins,Sabarish V. Indran,Igor Morozov,Jessie D. Trujillo,Yesai Fstkchyan,Raveen Rathnasinghe,Zeyu Zhu,Simin Zheng,Nan Zhao,Kris M. White,Helen Ray-Jones,Valeriya Malysheva,Michiel J. Thiecke,Siu Ying Lau,Honglian Liu,Anna Junxia Zhang,Andrew Chak-Yiu Lee,Wen-Chun Liu,Sonia Jangra,Alba Escalera,Teresa Aydillo,Betsaida Salom Melo,Ernesto Guccione,Robert Sebra,Elaine Shum,Jan Bakker,Jan Bakker,Jan Bakker,David A. Kaufman,Andre L. Moreira,Mariano Carossino,Udeni B. R. Balasuriya,Minji Byun,Randy A. Albrecht,Michael Schotsaert,Adolfo García-Sastre,Sumit K. Chanda,Emily R. Miraldi,Emily R. Miraldi,Anand D. Jeyasekharan,Benjamin R. tenOever,Mikhail Spivakov,Matthew T. Weirauch,Matthew T. Weirauch,Sven Heinz,Honglin Chen,Christopher Benner,Juergen A. Richt,Ivan Marazzi +57 more
TL;DR: In this paper, using multidimensional epigenetic, transcriptional, in-vitro, and invivo analyses, the authors reported that topoisomerase 1 (TOP1) inhibition suppresses lethal inflammation induced by SARS-CoV-2.
Journal ArticleDOI
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
Matthew S. Miller,Alexander Rialdi,Jessica Sook Yuin Ho,Micah Tilove,Luis Martínez-Gil,Natasha Moshkina,Zuleyma Peralta,Justine Noel,Camilla Melegari,Ana M. Maestre,Panagiotis Mitsopoulos,Joaquín Madrenas,Sven Heinz,Christopher Benner,John A. T. Young,Alicia R. Feagins,Christopher F. Basler,Ana Fernandez-Sesma,Olivier J. Becherel,Martin F. Lavin,Harm van Bakel,Ivan Marazzi +21 more
TL;DR: Mechanistically, a model whereby SETX attenuates the activity of RNA polymerase II at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses is proposed.
Journal ArticleDOI
Influenza virus infection causes global RNAPII termination defects
Nan Zhao,Vittorio Sebastiano,Natasha Moshkina,Nacho Mena,Judd F. Hultquist,David Jimenez-Morales,Yixuan Ma,Alex Rialdi,Randy A. Albrecht,Romain Fenouil,Maria Teresa Sánchez-Aparicio,Juan Ayllon,Sweta Ravisankar,Bahareh Haddad,Jessica Sook Yuin Ho,Diana Low,Jian Jin,Vyacheslav Yurchenko,Rab K. Prinjha,Alexander Tarakhovsky,Massimo Squatrito,Dalila Pinto,Kimaada Allette,Minji Byun,Melissa Smith,Robert Sebra,Ernesto Guccione,Terrence M. Tumpey,Nevan J. Krogan,Benjamin Greenbaum,Harm van Bakel,Adolfo García-Sastre,Ivan Marazzi +32 more
TL;DR: Using cell biological, biochemical, and genetic tools, it is revealed that influenza A virus (IAV) infection induces global transcriptional defects at the 3′ ends of active host genes and RNA polymerase II (RNAPII) run-through into extragenic regions.