K
Kathy L. Sivils
Researcher at Oklahoma Medical Research Foundation
Publications - 92
Citations - 4946
Kathy L. Sivils is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Lupus erythematosus & Genome-wide association study. The author has an hindex of 31, co-authored 81 publications receiving 3407 citations. Previous affiliations of Kathy L. Sivils include University of Oklahoma & University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Sjögren syndrome
Pilar Brito-Zerón,W. Baldini,Hendrika Bootsma,Simon J. Bowman,Roland Jonsson,Xavier Mariette,Kathy L. Sivils,Elke Theander,Athanasios G. Tzioufas,Manuel Ramos-Casals +9 more
TL;DR: Knowledge of SjS has progressed substantially, but this disease is still characterized by sicca symptoms, the systemic involvement of disease, lymphocytic infiltration to exocrine glands, the presence of anti-Ro/SSA and anti-La/SSB autoantibodies and the increased risk of lymphoma in patients with SJS.
Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Transancestral mapping and genetic load in systemic lupus erythematosus
Carl D. Langefeld,Hannah C. Ainsworth,Deborah S. Cunninghame Graham,Jennifer A. Kelly,Mary E. Comeau,Miranda C. Marion,Timothy D. Howard,Paula S. Ramos,Jennifer A. Croker,David L. Morris,Johanna K. Sandling,Jonas Carlsson Almlöf,Eduardo Acevedo-Vásquez,Graciela S. Alarcón,Alejandra Babini,Vicente Baca,Anders A. Bengtsson,Guillermo A. Berbotto,Marc Bijl,Elizabeth E. Brown,Hermine I. Brunner,Mario H. Cardiel,Luis J. Catoggio,Ricard Cervera,Jorge M. Cucho-Venegas,Solbritt Rantapää Dahlqvist,Sandra D'Alfonso,Berta Martins da Silva,Iñigo de la Rúa Figueroa,Andrea Doria,Jeffrey C. Edberg,Emőke Endreffy,Jorge A. Esquivel-Valerio,Paul R. Fortin,Barry I. Freedman,Johan Frostegård,Mercedes A. García,Ignacio García-De La Torre,Gary S. Gilkeson,Dafna D. Gladman,Iva Gunnarsson,Joel M. Guthridge,Jennifer Huggins,Judith A. James,Cees G. M. Kallenberg,Diane L. Kamen,David R. Karp,David R. Karp,Kenneth M. Kaufman,Leah C. Kottyan,László Kovács,Helle Laustrup,Helle Laustrup,Bernard Lauwerys,Quan Zhen Li,Quan Zhen Li,Marco A. Maradiaga-Ceceña,Javier Martín,Joseph M. McCune,David R. McWilliams,Joan T. Merrill,Pedro Miranda,José Francisco Moctezuma,Swapan K. Nath,Timothy B. Niewold,Lorena Orozco,Norberto Ortego-Centeno,Michelle Petri,Christian A. Pineau,Bernardo A. Pons-Estel,Janet E. Pope,Prithvi Raj,Prithvi Raj,Rosalind Ramsey-Goldman,John D. Reveille,John D. Reveille,John D. Reveille,Laurie P Russell,José Mario Sabio,Carlos A. Aguilar-Salinas,Hugo R. Scherbarth,Raffaella Scorza,Michael F. Seldin,Christopher Sjöwall,Elisabet Svenungsson,Susan D. Thompson,Sergio Toloza,Lennart Truedsson,Lennart Truedsson,Teresa Tusié-Luna,Carlos Vasconcelos,Luis M. Vilá,Luis M. Vilá,Daniel J. Wallace,Michael H. Weisman,Joan E. Wither,Tushar Bhangale,Jorge R. Oksenberg,John D. Rioux,Peter K. Gregersen,Ann-Christine Syvänen,Lars Rönnblom,Lindsey A. Criswell,Chaim O. Jacob,Kathy L. Sivils,Betty P. Tsao,Laura E. Schanberg,Timothy W. Behrens,Earl D. Silverman,Marta E. Alarcón-Riquelme,Robert P. Kimberly,John B. Harley,Edward K. Wakeland,Edward K. Wakeland,Robert R. Graham,Patrick M. Gaffney,Timothy J. Vyse +116 more
TL;DR: A large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European, African and Hispanic Amerindian ancestry identifies both ancestry-dependent and ancestry-independent contributions to SLE risk.
Journal ArticleDOI
Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI)
Raphaèle Seror,Raphaèle Seror,Hendrika Bootsma,Alain Saraux,Simon J Bowman,Elke Theander,Johan G. Brun,Gabriel Baron,Véronique Le Guern,Valérie Devauchelle-Pensec,Manel Ramos-Casals,Valeria Valim,Thomas Dörner,Athanasios G. Tzioufas,Jacques-Eric Gottenberg,Roser Solans Laqué,Thomas Mandl,Eric Hachulla,Kathy L. Sivils,Wan-Fai Ng,Anne-Laure Fauchais,Stefano Bombardieri,Roberta Priori,Elena Bartoloni,Vincent Goëb,Sonja Praprotnik,Takayuki Sumida,Sumusu Nishiyama,Roberto Caporali,Aike A. Kruize,C. Vollenweider,Philippe Ravaud,Petra M. Meiners,Pilar Brito-Zerón,Claudio Vitali,Xavier Mariette +35 more
TL;DR: This study determined disease activity levels, PASS and MCII of ESSDAI and ESSPRI, which will help designing future clinical trials in SS and the proposal is to include patients with moderate activity and define response to treatment as an improvement of E SSDAI at least three points.
Journal ArticleDOI
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Barry I. Freedman,Carl D. Langefeld,Kelly K. Andringa,Jennifer A. Croker,Adrienne H. Williams,Neva E. Garner,Daniel J. Birmingham,Lee A. Hebert,Pamela J. Hicks,Mark S. Segal,Jeffrey C. Edberg,Elizabeth E. Brown,Graciela S. Alarcón,Karen H. Costenbader,Mary E. Comeau,Lindsey A. Criswell,John B. Harley,Judith A. James,Diane L. Kamen,S. Sam Lim,Joan T. Merrill,Kathy L. Sivils,Timothy B. Niewold,Neha M. Patel,Michelle Petri,Rosalind Ramsey-Goldman,John D. Reveille,Jane E. Salmon,Betty P. Tsao,Keisha L. Gibson,Joyce R. Byers,Anna K. Vinnikova,Janice P. Lea,Bruce A. Julian,Robert P. Kimberly +34 more
TL;DR: The hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans and rare in European Americans, contribute to the ethnic disparity in risk of lupus nephritis is investigated.