Katherine G. Zyner

TL;DR: The development of G4 ChIP–seq, an antibody-based G4 chromatin immunoprecipitation and high-throughput sequencing approach, shows that regulatory, nucleosome-depleted chromatin and elevated transcription shape the endogenous human G4 DNA landscape.

TL;DR: This Review discusses the identification of G4s and evidence for their formation in cells using chemical biology, imaging and genomic technologies, and discusses the connection between G4 formation and synthetic lethality in cancer cells, and recent progress towards considering G 4s as therapeutic targets in human diseases.

TL;DR: It is demonstrated that human telomerase is able to extend parallel, intermolecular conformations in vitro, and this implies that parallel telomeric G-quadruplexes may play an important biological role.

TL;DR: It is demonstrated that coilin, an essential structural component of Cajal bodies, is required for endogenous telomerase recruitment to telomeres but that overexpression of telomersase can compensate for CajAl body absence.

TL;DR: The changes produced by CM03 represent a global response to the complexity of human PDAC and may be applicable to other currently hard-to-treat cancers.