K
Kathryn A. Larkin
Researcher at Stanford University
Publications - 2
Citations - 573
Kathryn A. Larkin is an academic researcher from Stanford University. The author has contributed to research in topics: LGR5 & Enteroendocrine cell. The author has an hindex of 2, co-authored 2 publications receiving 426 citations.
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Journal ArticleDOI
Non-equivalence of Wnt and R-spondin ligands during Lgr5 + intestinal stem-cell self-renewal
Kelley S. Yan,Kelley S. Yan,Claudia Y. Janda,Junlei Chang,Grace X.Y. Zheng,Kathryn A. Larkin,Vincent C. Luca,Luis A. Chia,Amanda T. Mah,Arnold Han,Arnold Han,Jessica M. Terry,Akifumi Ootani,Kelly Roelf,Mark Lee,Jenny Yuan,Xiao Li,Christopher R. Bolen,Julie Wilhelmy,Paige S. Davies,Hiroo Ueno,Richard J. von Furstenberg,Phillip Belgrader,Solongo B. Ziraldo,Heather Ordonez,Susan J. Henning,Melissa H. Wong,Michael Snyder,Irving L. Weissman,Aaron J. W. Hsueh,Tarjei S. Mikkelsen,K. Christopher Garcia,Calvin J. Kuo +32 more
TL;DR: This functionally non-equivalent yet cooperative interaction between Wnt and RSPO ligands establishes a molecular precedent for regulation of mammalian stem cells by distinct priming and self-renewal factors, with broad implications for precise control of tissue regeneration.
Journal ArticleDOI
Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.