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Christine A. Cartwright
Researcher at Stanford University
Publications - 53
Citations - 4430
Christine A. Cartwright is an academic researcher from Stanford University. The author has contributed to research in topics: Proto-oncogene tyrosine-protein kinase Src & Phosphorylation. The author has an hindex of 32, co-authored 53 publications receiving 4288 citations. Previous affiliations of Christine A. Cartwright include Johns Hopkins University School of Medicine & Uppsala University.
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Journal ArticleDOI
Tyr527 is phosphorylated in pp60c-src: implications for regulation.
TL;DR: Results suggest that the increase in transforming ability and kinase activity that occurred in the genesis of pp60v-src may have resulted from the loss of a tyrosine involved in negative regulation.
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Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain
TL;DR: The results suggest that one, inability to phosphorylate tyrosine 527 increases pp60c-src protein kinase activity and transforming ability; two, transformation by mT involves other events besides lack of phosphorylation at tyrosin 527 of pp60C-src; three, activation of the pp60 c-srcprotein kinase may not be required for transformation by the Am517 mutant; and four, the carboxyl terminus of pp 60c- src appears
Journal ArticleDOI
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.
TL;DR: Activity is highest in malignant polyps and in greater than 2-cm benign polyps that contain villous structure and severe dysplasia, suggesting that activation of the protooncogene product pp60c-src may be an important event in the genesis of human colon carcinoma.
Journal ArticleDOI
RACK1, a Receptor for Activated C Kinase and a Homolog of the β Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells
TL;DR: It is suggested that RACK1 exerts its effect on the NIH 3T3 cell cycle in part by inhibiting Src activity.
Journal ArticleDOI
Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.