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Katrina Podsypanina
Researcher at PSL Research University
Publications - 36
Citations - 9150
Katrina Podsypanina is an academic researcher from PSL Research University. The author has contributed to research in topics: PTEN & Cancer. The author has an hindex of 22, co-authored 35 publications receiving 8805 citations. Previous affiliations of Katrina Podsypanina include Kettering University & Curie Institute.
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Journal ArticleDOI
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jing Li,Clifford Yen,Danny Liaw,Katrina Podsypanina,Shikha Bose,Steven I. Wang,Janusz Puc,Christa Miliaresis,Linda Rodgers,Richard W. McCombie,Sandra H. Bigner,Beppino C. Giovanella,Michael Ittmann,B. Tycko,Hanina Hibshoosh,Michael Wigler,Ramon Parsons +16 more
TL;DR: The PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions as discussed by the authors.
Journal ArticleDOI
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Katrina Podsypanina,Lora Hedrick Ellenson,Adriana Nemes,Jianguo Gu,Masahito Tamura,Kenneth M. Yamada,Carlos Cordon-Cardo,Giorgio Catoretti,Peter E. Fisher,Ramon Parsons +9 more
TL;DR: Examination of peripheral lymphoid tissue including lymphoid aggregates associated with polyps revealed that the normal organization of B and T cells was disrupted in heterozygous animals, suggesting that PTEN is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressionor in other organs.
Journal ArticleDOI
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Katrina Podsypanina,Richard T. Lee,Chris Politis,Ian Hennessy,Allison Crane,Janusz Puc,Mehran S. Neshat,Hong Wang,Lin Yang,Jay Gibbons,Phil Frost,Valley C. Dreisbach,John Blenis,Zbigniew Gaciong,Peter E. Fisher,Charles L. Sawyers,Lora Hedrick-Ellenson,Ramon Parsons +17 more
TL;DR: It is shown that transformed cells of PTEN+/− mice have elevated levels of phosphorylated Akt and activated p70/S6 kinase associated with an increase in proliferation and that inhibition of these proteins may be therapeutic for cancer patients with deranged PI3K signaling.
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Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
Yi Li,Bryan E. Welm,Katrina Podsypanina,Shixia Huang,Mario Chamorro,Xiaomei Zhang,Tracey M Rowlands,Mikala Egeblad,Pamela Cowin,Zena Werb,Lee K. Tan,Jeffrey M. Rosen,Harold E. Varmus +12 more
TL;DR: The results suggest that mammary stem cells and/or progenitors to mammary luminal epithelial and myoepithelial cells may be the targets for oncogenesis by Wnt-1 signaling elements.
Journal ArticleDOI
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Bernard Kwabi-Addo,Dipak Giri,Karen Schmidt,Katrina Podsypanina,Ramon Parsons,Norman M. Greenberg,Michael Ittmann +6 more
TL;DR: Analysis of prostate cancer progression in transgenic adenocarcinoma of mouse prostate mice bred to Pten+/− heterozygous mice, coupled with analysis of the Pten gene and protein in the resulting tumors, reveals that haploinsufficiency of thePten gene promotes the progression of prostatecancer in this model system.