Kausik Regunath

TL;DR: It is demonstrated that repression of the mevalonate pathway is a crucial component of p53-mediated liver tumor suppression and the mechanism by which this occurs is outlined.

TL;DR: It is surmised that mutant p53 impacts transcription of VEGFR2 as well as myriad other genes by promoter remodeling through interaction with and likely regulation of the SWI/SNF chromatin remodeling complex, which means that not only might mutants p53-expressing tumors be susceptible to anti VEGF therapies, impacting SWI-SNF tumor suppressor function in mutant p 53 tumors may also have therapeutic potential.

TL;DR: A pathway by which RAS and PIK3CA oncogenes induce EMT through regulation of ∆Np63α is suggested, which suggests that targeting specific genes within this Ras-to-EMT axis may be useful as a therapy to block breast cancer progression.

TL;DR: Together, the results indicate that TAB1 is a potential tumor suppressor that serves as a functional link between p53-MDM2 circuitry and a key MAPK signaling pathway.

TL;DR: In this paper, the authors characterized three p53 frameshift mutant proteins expressed from the endogenous TP53 locus in U2OS osteosarcoma and HCT116 colorectal cancer cell lines.