E
Edward R. Kastenhuber
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 42
Citations - 4722
Edward R. Kastenhuber is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Carcinogenesis & Medicine. The author has an hindex of 25, co-authored 34 publications receiving 3495 citations. Previous affiliations of Edward R. Kastenhuber include Kettering University & University of Pittsburgh.
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Journal ArticleDOI
Putting p53 in Context
TL;DR: TP53 is the most frequently mutated gene in human cancer and must be interpreted to understand how cell type, mutation profile, and epigenetic cell state dictate outcomes, and how might it restore its tumor-suppressive activities in cancer.
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Inducible in vivo genome editing with CRISPR-Cas9
Lukas E. Dow,Lukas E. Dow,Jonathan Fisher,Kevin P. O’Rourke,Kevin P. O’Rourke,Ashlesha Muley,Edward R. Kastenhuber,Edward R. Kastenhuber,Geulah Livshits,Darjus F. Tschaharganeh,Nicholas D. Socci,Scott W. Lowe +11 more
TL;DR: It is shown that doxycycline-regulated Cas9 induction enables widespread gene disruption in multiple tissues and that limiting the duration of Cas9 expression or using a Cas9D10A (Cas9n) variant can regulate the frequency and size of target gene modifications, respectively.
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Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
Kasthuri Kannan,Akiko Inagaki,Joachim Silber,Daniel Gorovets,Jianan Zhang,Edward R. Kastenhuber,Adriana Heguy,John H.J. Petrini,Timothy A. Chan,Jason T. Huse +9 more
TL;DR: These findings both identify ATRX mutation as a defining molecular determinant for a large subset of IDH-mutant gliomas and have direct implications on pathogenic mechanisms across the wide spectrum of LGGs.
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Optimized base editors enable efficient editing in cells, organoids and mice.
Maria Paz Zafra,Emma M Schatoff,Emma M Schatoff,Alyna Katti,Miguel Foronda,Marco Breinig,Anabel Y Schweitzer,Amber Simon,Teng Han,Sukanya Goswami,Emma Montgomery,Jordana K. Thibado,Edward R. Kastenhuber,Edward R. Kastenhuber,Francisco J. Sánchez-Rivera,Junwei Shi,Junwei Shi,Christopher R. Vakoc,Scott W. Lowe,Darjus F. Tschaharganeh,Lukas E. Dow +20 more
TL;DR: This work reengineered the sequences of BE3, BE4Gam, and xBE3 by codon optimization and incorporation of additional nuclear-localization sequences and shows that the optimized base editors mediate efficient in vivo somatic editing in the liver in adult mice.
Journal ArticleDOI
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Sung-Hwan Moon,Chun-Hao Huang,Chun-Hao Huang,Chun-Hao Huang,Shauna L. Houlihan,Kausik Regunath,William A. Freed-Pastor,John P. Morris,Darjus F. Tschaharganeh,Edward R. Kastenhuber,Anthony M. Barsotti,Rachel Culp-Hill,Wen Xue,Yu-Jui Ho,Timour Baslan,Xiang Li,Xiang Li,Allison Mayle,Elisa de Stanchina,Lars Zender,David R. Tong,Angelo D'Alessandro,Scott W. Lowe,Carol Prives +23 more
TL;DR: It is demonstrated that repression of the mevalonate pathway is a crucial component of p53-mediated liver tumor suppression and the mechanism by which this occurs is outlined.