S
Shauna L. Houlihan
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 7
Citations - 806
Shauna L. Houlihan is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Fusion gene & Fusion protein. The author has an hindex of 4, co-authored 7 publications receiving 366 citations.
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Journal ArticleDOI
Senolytic CAR T cells reverse senescence-associated pathologies.
Corina Amor,Judith Feucht,Josef Leibold,Yu-Jui Ho,Changyu Zhu,Direna Alonso-Curbelo,Jorge Mansilla-Soto,Jacob A. Boyer,Xiang Li,Xiang Li,Theodoros Giavridis,Amanda Kulick,Shauna L. Houlihan,Ellinor I.B. Peerschke,Scott L. Friedman,Vladimir Ponomarev,Alessandra Piersigilli,Michel Sadelain,Scott W. Lowe,Scott W. Lowe +19 more
TL;DR: Chimeric antigen receptor (CAR) T cells targeting uPAR, a cell-surface protein that is upregulated on senescent cells, eliminate senescence cells in vitro and in vivo and reduce liver fibrosis in mice.
Journal ArticleDOI
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
Sung-Hwan Moon,Chun-Hao Huang,Chun-Hao Huang,Chun-Hao Huang,Shauna L. Houlihan,Kausik Regunath,William A. Freed-Pastor,John P. Morris,Darjus F. Tschaharganeh,Edward R. Kastenhuber,Anthony M. Barsotti,Rachel Culp-Hill,Wen Xue,Yu-Jui Ho,Timour Baslan,Xiang Li,Xiang Li,Allison Mayle,Elisa de Stanchina,Lars Zender,David R. Tong,Angelo D'Alessandro,Scott W. Lowe,Carol Prives +23 more
TL;DR: It is demonstrated that repression of the mevalonate pathway is a crucial component of p53-mediated liver tumor suppression and the mechanism by which this occurs is outlined.
Journal ArticleDOI
DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma
Edward R. Kastenhuber,Gadi Lalazar,Shauna L. Houlihan,Darjus F. Tschaharganeh,Timour Baslan,Chi-Chao Chen,David Requena,Sha Tian,Benedikt Bosbach,John E. Wilkinson,Sanford M. Simon,Scott W. Lowe +11 more
TL;DR: It is demonstrated that the Dnajb1–Prkaca gene fusion drives tumorigenesis in mice, and that fusion to DNAJB1 drives FL-HCC initiation more effectively than wild-type PRKACA overexpression.
Journal ArticleDOI
Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program
Kathryn T. Bieging-Rolett,Alyssa M. Kaiser,David W. Morgens,Anthony M. Boutelle,Jose A. Seoane,Eric L. Van Nostrand,Changyu Zhu,Shauna L. Houlihan,Stephano S. Mello,Brian A. Yee,Jacob McClendon,Sarah E. Pierce,Ian P. Winters,Mengxiong Wang,Andrew J. Connolly,Scott W. Lowe,Christina Curtis,Gene W. Yeo,Monte M. Winslow,Michael C. Bassik,Laura D. Attardi +20 more
TL;DR: Unbiased RNAi and CRISPR-Cas9-based genetic screens in vivo reveal ZMAT3 as a novel RNA-splicing and homeostasis regulator and a key component of p53-mediated tumor suppression.
Journal ArticleDOI
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.
Archna Ravi,Lavinia Palamiuc,Ryan M. Loughran,Joanna Triscott,Gurpreet K. Arora,Avi Kumar,Vivian Tieu,Chantal Pauli,Matthias Reist,Rachel J. Lew,Shauna L. Houlihan,Christof Fellmann,Christof Fellmann,Christian M. Metallo,Mark A. Rubin,Brooke M. Emerling +15 more
TL;DR: In this article, the authors identify a role for peroxisomal PI-4,5-P2 generated by the PI5P4Ks in maintaining energy balance.