K
Keunsoo Kang
Researcher at Dankook University
Publications - 147
Citations - 3690
Keunsoo Kang is an academic researcher from Dankook University. The author has contributed to research in topics: Gene & DNA methylation. The author has an hindex of 29, co-authored 127 publications receiving 2712 citations. Previous affiliations of Keunsoo Kang include Louisiana State University & KAIST.
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Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model
TL;DR: The result showed that atazanavir, an antiretroviral medication used to treat and prevent the human immunodeficiency virus (HIV), is the best chemical compound, showing an inhibitory potency with Kd of 94.94 nM against the SARS-CoV-2 3C-like proteinase.
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AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2
TL;DR: This study characterized this unknown protein and tested its potential targeting roles for the mammalian Polycomb Repression Complex 2 (PRC2), suggesting that AEBP2 is most likely a targeting protein for the mammal PRC2 complex.
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Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
Sung Ho Park,Kyuho Kang,Eugenia G. Giannopoulou,Eugenia G. Giannopoulou,Yu Qiao,Keunsoo Kang,Geonho Kim,Kyung-Hyun Park-Min,Lionel B. Ivashkiv,Lionel B. Ivashkiv +9 more
TL;DR: The findings reveal that signaling crosstalk between interferons and TNF is integrated at the level of chromatin to reprogram inflammatory responses, and identify previously unknown functions and mechanisms of action of these cytokines.
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A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness
Tackhoon Kim,Suk Jin Yang,Daehee Hwang,Jinhoi Song,Minchul Kim,Sang Kyum Kim,Keunsoo Kang,Jaebum Ahn,Daeyoup Lee,Miyoung Kim,Seyun Kim,Ja Seung Koo,Sang Seok Koh,Seon-Young Kim,Dae-Sik Lim +14 more
TL;DR: The results establish the importance of SRF–YAP–IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner and show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer.
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Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF
Kyuho Kang,Kyuho Kang,Sung Ho Park,Janice Chen,Yu Qiao,Eugenia G. Giannopoulou,Eugenia G. Giannopoulou,Karen Berg,Adedayo Hanidu,Jun Li,Gerald Nabozny,Keunsoo Kang,Kyung-Hyun Park-Min,Lionel B. Ivashkiv,Lionel B. Ivashkiv +14 more
TL;DR: The results identify enhancer inactivation and disassembly as a mechanism of IFN‐&ggr;‐mediated gene repression and reveal that MAF regulates the macrophage enhancer landscape and is suppressed by IFN; to augment macrophages activation.