Kevin A. Feeney

TL;DR: It is shown that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms and exploring the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system.

TL;DR: In this article, the intracellular concentration of magnesium ions, [Mg(2+)]i, was found to act as a cell-autonomous timekeeping component to determine key clock properties both in a human cell line and in a unicellular alga.

TL;DR: It is suggested that circadian regulation of the cytoskeleton influences wound-healing efficacy from the cellular to the organismal scale, as well as the observation that the time of injury significantly affects healing after burns in humans, with daytime wounds healing faster than nighttime wounds.

TL;DR: The pentose phosphate pathway (PPP), a critical source of the redox cofactor NADPH, is identified as an important regulator of redox and transcriptional oscillations, suggesting a pivotal role for NADPH availability in circadian timekeeping.

TL;DR: Comparative chronobiology is used to distinguish fundamental clock mechanisms from species and/or tissue-specific adaptations and thereby identify features shared between circadian rhythms in mammalian cells and non-circadian temperature-compensated respiratory oscillations in budding yeast.