K
Kikuko Hotta
Researcher at Osaka Ohtani University
Publications - 77
Citations - 20366
Kikuko Hotta is an academic researcher from Osaka Ohtani University. The author has contributed to research in topics: Single-nucleotide polymorphism & Nonalcoholic fatty liver disease. The author has an hindex of 36, co-authored 76 publications receiving 19606 citations. Previous affiliations of Kikuko Hotta include Kyoto University & Osaka University.
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Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Journal ArticleDOI
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
Christian Weyer,Tohru Funahashi,Sachiyo Tanaka,Kikuko Hotta,Yuji Matsuzawa,Richard E. Pratley,P. Antonio Tataranni +6 more
TL;DR: It is confirmed that obesity and type 2 diabetes are associated with low plasma adiponectin concentrations in different ethnic groups and indicate that the degree of hypoadiponectinemia is more closely related to thedegree of insulin resistance and hyperinsulinemia than to the level of adiposity and glucose intolerance.
Journal ArticleDOI
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Kikuko Hotta,Tohru Funahashi,Yukio Arita,Masahiko Takahashi,Morihiro Matsuda,Yoshihisa Okamoto,Hiromi Iwahashi,Hiroshi Kuriyama,Noriyuki Ouchi,Kazuhisa Maeda,Makoto Nishida,Shinji Kihara,Naohiko Sakai,Tadahisa Nakajima,Kyoichi Hasegawa,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Toshiaki Hanafusa,Yuji Matsuzawa +20 more
TL;DR: Results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy, and weight reduction significantly elevated plasma adip onectin levels in the diabetic subjects as well as the nondiabetic subjects.
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Novel Modulator for Endothelial Adhesion Molecules: Adipocyte-Derived Plasma Protein Adiponectin
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Kazuhisa Maeda,Hiroshi Kuriyama,Yoshihisa Okamoto,Kikuko Hotta,Makoto Nishida,Masahiko Takahashi,Tadashi Nakamura,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +12 more
TL;DR: Observations suggest that adiponectin modulates endothelial inflammatory response and that the measurement of plasma adiponECTin levels may be helpful in assessment of CAD risk.
Journal ArticleDOI
PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein
Norikazu Maeda,Masahiko Takahashi,Tohru Funahashi,Shinji Kihara,Hitoshi Nishizawa,Ken Kishida,Hiroyuki Nagaretani,Morihiro Matsuda,Ryutaro Komuro,Noriyuki Ouchi,Hiroshi Kuriyama,Kikuko Hotta,Tadashi Nakamura,Iichiro Shimomura,Yuji Matsuzawa +14 more
TL;DR: Thiazolidinediones (TZDs) might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponECTin promoter.