K
Kirk E. Lohmueller
Researcher at University of California, Los Angeles
Publications - 119
Citations - 12092
Kirk E. Lohmueller is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Population & Natural selection. The author has an hindex of 40, co-authored 107 publications receiving 10556 citations. Previous affiliations of Kirk E. Lohmueller include Georgetown University & University of Washington.
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Journal ArticleDOI
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.
Kirk E. Lohmueller,Celeste Leigh Pearce,Malcolm C. Pike,Eric S. Lander,Joel N. Hirschhorn,Joel N. Hirschhorn +5 more
TL;DR: It is concluded that there are probably many common variants in the human genome with modest but real effects on common disease risk, and that studies using large samples will convincingly identify such variants.
Journal ArticleDOI
A comprehensive review of genetic association studies.
TL;DR: It is found that over 600 positive associations between common gene variants and disease have been reported; these associations, if correct, would have tremendous importance for the prevention, prediction, and treatment of most common diseases.
Journal ArticleDOI
Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
Bridgett M. vonHoldt,John P. Pollinger,Kirk E. Lohmueller,Eunjung Han,Heidi G. Parker,Pascale Quignon,Jeremiah D. Degenhardt,Adam R. Boyko,Dent Earl,Adam Auton,Andrew R. Reynolds,Kasia Bryc,Abra Brisbin,James C. Knowles,Dana S. Mosher,Tyrone C. Spady,Abdel G. Elkahloun,Eli Geffen,Malgorzata Pilot,Włodzimierz Jędrzejewski,Claudia Greco,Ettore Randi,Danika L. Bannasch,Alan N. Wilton,Jeremy R. Shearman,Marco Musiani,Michelle Cargill,Paul Glyn Jones,Zuwei Qian,Wei Huang,Zhao Li Ding,Ya-Ping Zhang,Carlos Bustamante,Elaine A. Ostrander,John Novembre,Robert K. Wayne +35 more
TL;DR: It is shown that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data.
Journal ArticleDOI
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
Adam R. Boyko,Scott Williamson,Amit Indap,Jeremiah D. Degenhardt,Ryan D. Hernandez,Kirk E. Lohmueller,Mark Raymond Adams,Steffen Schmidt,John J. Sninsky,Shamil R. Sunyaev,Thomas J. White,Rasmus Nielsen,Andrew G. Clark,Carlos Bustamante +13 more
TL;DR: The analysis predicts that many of the alleles identified via whole-genome association mapping may be selectively neutral or (formerly) positively selected, implying that deleterious genetic variation affecting disease phenotype may be missed by this widely used approach for mapping genes underlying complex traits.
Journal ArticleDOI
An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia
Morten Rasmussen,Xiaosen Guo,Yong Wang,Kirk E. Lohmueller,Simon Rasmussen,Anders Albrechtsen,Line Skotte,Stinus Lindgreen,Mait Metspalu,Thibaut Jombart,Toomas Kivisild,Weiwei Zhai,Anders Eriksson,Andrea Manica,Ludovic Orlando,Francisco M. De La Vega,Silvana R. Tridico,Ene Metspalu,Kasper Nielsen,María C. Ávila-Arcos,J. Víctor Moreno-Mayar,J. Víctor Moreno-Mayar,Craig Muller,Joe Dortch,M. Thomas P. Gilbert,Ole Lund,Agata Wesolowska,Monika Karmin,Lucy A. Weinert,Bo Wang,Jun Li,Shuaishuai Tai,Fei Xiao,Tsunehiko Hanihara,George van Driem,Aashish R. Jha,François-Xavier Ricaut,Peter de Knijff,Andrea Bamberg Migliano,Andrea Bamberg Migliano,Irene Gallego Romero,Karsten Kristiansen,David M. Lambert,Søren Brunak,Søren Brunak,Peter Forster,Bernd Brinkmann,Olaf Nehlich,Michael Bunce,Michael P. Richards,Michael P. Richards,Ramneek Gupta,Carlos Bustamante,Anders Krogh,Robert Foley,Marta Mirazón Lahr,Francois Balloux,Thomas Sicheritz-Pontén,Richard Villems,Richard Villems,Rasmus Nielsen,Rasmus Nielsen,Jun Wang,Eske Willerslev +63 more
TL;DR: It is shown that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago, which is separate from the one that gave rise to modern Asians 25, thousands of years ago.