M
Masaki Tsunoda
Publications - 7
Citations - 6412
Masaki Tsunoda is an academic researcher. The author has contributed to research in topics: Insulin resistance & Adiponectin. The author has an hindex of 6, co-authored 7 publications receiving 6060 citations.
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Journal ArticleDOI
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Toshimasa Yamauchi,Junji Kamon,Yusuke Ito,Atsushi Tsuchida,Takehiko Yokomizo,Takehiko Yokomizo,Shunbun Kita,Takuya Sugiyama,Makoto Miyagishi,Makoto Miyagishi,Kazuo Hara,Masaki Tsunoda,Koji Murakami,Toshiaki Ohteki,S. Uchida,Sato Takekawa,Hironori Waki,Nelson H. Tsuno,Yoichi Shibata,Yasuo Terauchi,Philippe Froguel,Kazuyuki Tobe,Shigeo Koyasu,Kazunari Taira,Kazunari Taira,Toshio Kitamura,Takao Shimizu,Takao Shimizu,Ryozo Nagai,Takashi Kadowaki +29 more
TL;DR: The cloning of complementary DNAs encoding adiponectin receptors 1 and 2 by expression cloning supports the conclusion that they serve as receptors for globular and full-length adiponECTin, and that they mediate increased AMP kinase and PPAR-α ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectionin.
Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
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Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasushi Imai,Nobuhiro Shimozawa,K. Hioki,S. Uchida,Yusuke Ito,Keisuke Takakuwa,Junji Matsui,Makoto Takata,Kazuhiro Eto,Yasuo Terauchi,Kajuro Komeda,Masaki Tsunoda,Koji Murakami,Yasuyuki Ohnishi,Takeshi Naitoh,Ken Ichi Yamamura,Yoshito Ueyama,Philippe Froguel,Satoshi Kimura,A. Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is shown that replenishment of globular adiponectin may provide a novel treatment modality for both type 2 diabetes and atherosclerosis, and this is the first demonstration that globular leptin can protect against Atherosclerosis in vivo.
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Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance
Nozomu Kamei,Kazuyuki Tobe,Ryo Suzuki,Mitsuru Ohsugi,Taku Watanabe,Naoto Kubota,Norie Ohtsuka-Kowatari,Katsuyoshi Kumagai,Kentaro Q. Sakamoto,Masatoshi Kobayashi,Toshimasa Yamauchi,Kohjiro Ueki,Yumiko Oishi,Satoshi Nishimura,Ichiro Manabe,Haruo Hashimoto,Yasuyuki Ohnishi,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
Journal ArticleDOI
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Tetsuya Kubota,Naoto Kubota,Hiroki Kumagai,Shinichi Yamaguchi,Hideki Kozono,Takehiro Takahashi,Mariko Inoue,Shinsuke Itoh,Iseki Takamoto,Takayoshi Sasako,Katsuyoshi Kumagai,Tomoko Kawai,Shinji Hashimoto,Tsuneo Kobayashi,Maki Sato,Kumpei Tokuyama,Satoshi Nishimura,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Tomomi Yamazaki,Osamu Ezaki,Koichi Kawamura,Hirotake Masuda,Masao Moroi,Kaoru Sugi,Yuichi Oike,Hiroaki Shimokawa,Nobuyuki Yanagihara,Masato Tsutsui,Yasuo Terauchi,Kazuyuki Tobe,Ryozo Nagai,Katsuo Kamata,Kenji Inoue,Tatsuhiko Kodama,Kohjiro Ueki,Takashi Kadowaki +37 more
TL;DR: The results show that insulin signaling in endothelial cells plays a pivotal role in the regulation of glucose uptake by skeletal muscle, and improving endothelial insulin signaling may serve as a therapeutic strategy for ameliorating skeletal muscle insulin resistance.