T
Toshiyuki Maki
Researcher at University of Tokyo
Publications - 12
Citations - 2608
Toshiyuki Maki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Adipokine & Adiponectin. The author has an hindex of 10, co-authored 12 publications receiving 2461 citations.
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Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.
Journal ArticleDOI
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity
Atsushi Tsuchida,Toshimasa Yamauchi,Yusuke Ito,Yusuke Hada,Toshiyuki Maki,Sato Takekawa,Junji Kamon,Masaki Kobayashi,Ryo Suzuki,Kazuo Hara,Naoto Kubota,Yasuo Terauchi,Philippe Froguel,Jun Nakae,Masato Kasuga,Domenico Accili,Kazuyuki Tobe,Kohjiro Ueki,Ryozo Nagai,Takashi Kadowaki +19 more
TL;DR: The expression of AdipoR1/R2 appears to be inversely regulated by insulin in physiological and pathophysiological states such as fasting/refeeding, insulin deficiency, and hyper-insulinemia models via the insulin/phosphoinositide 3-kinase/Foxo1 pathway and is correlated with adiponectin sensitivity.
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Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination.
Atsushi Tsuchida,Toshimasa Yamauchi,Sato Takekawa,Yusuke Hada,Yusuke Ito,Toshiyuki Maki,Takashi Kadowaki +6 more
TL;DR: ptive activation of peroxisome proliferator-activated receptor (PPAR)alpha, PPARgamma, and both of them in combination in obese diabetic KKAy mice markedly improved insulin sensitivity and dual activation of PPARalpha and -gamma enhances the action of adip onectin by increasing both adiponectin and AdipoRs, which can result in the amelioration of obesity-induced insulin resistance.
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
Naoto Kubota,Yasuo Terauchi,Kazuyuki Tobe,Wataru Yano,Ryo Suzuki,Kohjiro Ueki,Iseki Takamoto,Hidemi Satoh,Toshiyuki Maki,Tetsuya Kubota,Masao Moroi,Miki Okada-Iwabu,Osamu Ezaki,Ryozo Nagai,Yoichi Ueta,Takashi Kadowaki,Tetsuo Noda +16 more
TL;DR: It is concluded that, in beta cells and the hypothalamus, Irs2 is crucially involved in the regulation of beta cell mass and leptin sensitivity.
Journal ArticleDOI
Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2.
Makoto Ishikawa,Joji Kitayama,Toshimasa Yamauchi,Takashi Kadowaki,Toshiyuki Maki,Hideyo Miyato,Hiroharu Yamashita,Hirokazu Nagawa +7 more
TL;DR: The results suggest that the antitumor effect of adiponectin was, at least partially, dependent on the direct effects on tumor cells.