O
Onisha Patel
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 50
Citations - 5590
Onisha Patel is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: T-cell receptor & Natural killer T cell. The author has an hindex of 28, co-authored 44 publications receiving 4795 citations. Previous affiliations of Onisha Patel include The Heart Research Institute & Monash University.
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Journal ArticleDOI
MR1 presents microbial vitamin B metabolites to MAIT cells
Lars Kjer-Nielsen,Onisha Patel,Alexandra J. Corbett,Jérôme Le Nours,Jérôme Le Nours,Bronwyn S. Meehan,Ligong Liu,Mugdha Bhati,Zhenjun Chen,Lyudmila Kostenko,Rangsima Reantragoon,Nicholas A. Williamson,Anthony W. Purcell,Anthony W. Purcell,Nadine L. Dudek,Nadine L. Dudek,Malcolm J. McConville,Richard A. J. O'Hair,George N. Khairallah,Dale I. Godfrey,David P. Fairlie,Jamie Rossjohn,Jamie Rossjohn,Jamie Rossjohn,James McCluskey +24 more
TL;DR: It is shown that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance, and data suggest that MAIT cells use these metabolites to detect microbial infection.
Journal ArticleDOI
T-cell activation by transitory neo-antigens derived from distinct microbial pathways
Alexandra J. Corbett,Sidonia B G Eckle,Richard W Birkinshaw,Ligong Liu,Onisha Patel,Jennifer Mahony,Zhenjun Chen,Rangsima Reantragoon,Bronwyn S. Meehan,Hanwei Cao,Nicholas A. Williamson,Richard A. Strugnell,Douwe van Sinderen,Jeffrey Y. W. Mak,David P. Fairlie,Lars Kjer-Nielsen,Jamie Rossjohn,James McCluskey +17 more
TL;DR: It is shown that MAIT-cell activation requires key genes encoding enzymes that form 5-amino-6-d-ribitylaminouracil (5-A-RU), an early intermediate in bacterial riboflavin synthesis, and MR1 is able to capture, stabilize and present chemically unstable pyrimidine intermediates, which otherwise convert to lumazines, as potent antigens to MAIT cells.
Journal ArticleDOI
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Rangsima Reantragoon,Alexandra J. Corbett,Isaac G. Sakala,Nicholas A Gherardin,Nicholas A Gherardin,John B. Furness,Zhenjun Chen,Sidonia B G Eckle,Adam P Uldrich,Richard W Birkinshaw,Onisha Patel,Lyudmila Kostenko,Bronwyn S. Meehan,Katherine Kedzierska,Ligong Liu,David P. Fairlie,Ted H. Hansen,Dale I. Godfrey,Jamie Rossjohn,Jamie Rossjohn,James McCluskey,Lars Kjer-Nielsen +21 more
TL;DR: Generation of antigen-loaded MR1 tetramers that specifically stain MAIT cells identifies heterogeneity in phenotypes and TCR repertoires in humans and mice.
Journal ArticleDOI
Recognition of CD1d-restricted antigens by natural killer T cells
TL;DR: This Review focuses on the defining features and emerging generalities regarding how NKT cells specifically recognize self, microbial and synthetic lipid-based antigens that are presented by CD1d.
Journal ArticleDOI
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Isabelle S Lucet,Emmanuelle Fantino,Emmanuelle Fantino,Michelle Leanne Styles,Michelle Leanne Styles,Rebecca S. Bamert,Rebecca S. Bamert,Onisha Patel,Onisha Patel,Sophie E. Broughton,Sophie E. Broughton,Mark Walter,Mark Walter,Christopher J. Burns,Christopher J. Burns,Herbert R. Treutlein,Herbert R. Treutlein,Andrew F. Wilks,Andrew F. Wilks,Jamie Rossjohn,Jamie Rossjohn +20 more
TL;DR: In this article, a crystal structure of the active conformation of the JAK2 PTK domain in complex with a high-affinity, pan-JAK inhibitor appears to bind via an induced fit mechanism.