Kyle M. Hernandez

TL;DR: It is revealed that G×E is common, often caused by changes in the magnitude of genetic effects in response to the environment, and associated with diverse genetic factors and molecular variants.

TL;DR: The results indicate that lack of spontaneous immune infiltration in solid tumors is unlikely to be due to lack of antigens, and strategies that improve T-cell infiltration into tumors may therefore be able to facilitate clinical response to immunotherapy once antIGens become recognized.

TL;DR: A label-free proteomic workflow is developed to analyse as few as 5,000 formalin-fixed, paraffin-embedded cells microdissected from each compartment and finds that stromal methyltransferase nicotinamide N-methyltransferase (NNMT) regulates the transition of normal fibroblasts to cancer-associated fibro Blasts through histone methylation and promotes ovarian cancer growth and metastasis.

TL;DR: The putative precursor lesions for HGSOC, STIC, possess most of the genomic aberrations present in advanced cancers, and a proportion of STIC represent intraepithelial metastases to the fallopian tube rather than the origin of H GSOC.

TL;DR: The results demonstrate that the hg19 and hg38 TCGA datasets are very highly concordant, promote informed use of either legacy or harmonized omics data, and provide a rubric that encourages similar comparisons as new data emerge and reference data evolve.