Samantha M. Tienda

TL;DR: Investigation of human endometrial cancer in which a hotspot R298P mutation is present in a key component of the methyltransferase complex reveals reduced m6A mRNA methylation as an oncogenic mechanism in endometricrial cancer and identifies m 6A methylationAs a regulator of AKT signalling.

TL;DR: A label-free proteomic workflow is developed to analyse as few as 5,000 formalin-fixed, paraffin-embedded cells microdissected from each compartment and finds that stromal methyltransferase nicotinamide N-methyltransferase (NNMT) regulates the transition of normal fibroblasts to cancer-associated fibro Blasts through histone methylation and promotes ovarian cancer growth and metastasis.

TL;DR: This review examines the clinical and genomic features that have been associated with long-term survival, which is generally defined as survival of >7-10years after initial diagnosis, and predicts that consistent selection of control and LTS groups, combined with the use of emerging transcriptomic, epigenomic, and proteomic platforms, is likely to identify conserved features associated withLong- term survival.

TL;DR: A platform that integrates family-wide chemical probes with proximity-dependent oligonucleotide amplification and imaging to quantify enzyme activity in native contexts with high spatial resolution is reported.

TL;DR: Using mouse models of metastasis, data identify an involvement of oncogenic p53 mutations in LPA signaling and HGSOC progression through regulation of ACP6 expression.