L
Laure Michel
Researcher at French Institute of Health and Medical Research
Publications - 60
Citations - 2335
Laure Michel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 21, co-authored 46 publications receiving 1736 citations. Previous affiliations of Laure Michel include Université de Montréal & University of Rennes.
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Journal ArticleDOI
Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study.
Alvaro Cobo-Calvo,Anne Ruiz,Elisabeth Maillart,Bertrand Audoin,Hélène Zéphir,Bertrand Bourre,Jonathan Ciron,Nicolas Collongues,David Brassat,François Cotton,Caroline Papeix,Françoise Durand-Dubief,David Laplaud,Romain Deschamps,Mikael Cohen,Damien Biotti,Xavier Ayrignac,Caroline Tilikete,Eric Thouvenot,Bruno Brochet,Cécile Dulau,Thibault Moreau,Ayman Tourbah,Pierre Lebranchu,Laure Michel,Christine Lebrun-Frenay,Alexis Montcuquet,Guillaume Mathey,Marc Debouverie,Jean Pelletier,Pierre Labauge,Nathalie Derache,M. Coustans,Fabien Rollot,Jérôme De Seze,Sandra Vukusic,Romain Marignier +36 more
TL;DR: In adults, MOG-Ab-associated disease extends beyond clinical and radiologic abnormalities in the optic nerve and spinal cord and despite the relapsing course, the overall visual and motor outcome is better compared with AQP4- Ab-positive patients.
Journal ArticleDOI
Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy
Rui Li,Ayman Rezk,Yusei Miyazaki,Ellen Hilgenberg,Hanane Touil,Ping Shen,Craig S. Moore,Laure Michel,Faisal Althekair,Sathy Rajasekharan,Jennifer L. Gommerman,Alexandre Prat,Simon Fillatreau,Amit Bar-Or +13 more
TL;DR: A proinflammatory, granulocyte macrophage–colony stimulating factor (GM-CSF)–expressing human memory B cell subset is described that is increased in frequency and more readily induced in multiple sclerosis (MS) patients compared to healthy controls.
Journal ArticleDOI
Tolerant Kidney Transplant Patients Produce B Cells with Regulatory Properties
Mélanie Chesneau,Laure Michel,Emilie Dugast,Alexis Chenouard,Alexis Chenouard,Daniel Baron,Daniel Baron,Annaïck Pallier,Justine Durand,Justine Durand,Faouzi Braza,Faouzi Braza,Pierrick Guerif,David-Axel Laplaud,David-Axel Laplaud,Jean-Paul Soulillou,Jean-Paul Soulillou,Magali Giral,Magali Giral,Nicolas Degauque,Nicolas Degauque,Elise Chiffoleau,Elise Chiffoleau,Sophie Brouard,Sophie Brouard +24 more
TL;DR: Insight is provided into the characterization of B cell-mediated immunoregulation in clinical tolerance and a potential regulatory effect of B cells on effector T cells in blood from patients with operationally tolerant kidney grafts are shown.
Journal ArticleDOI
Unique B cell differentiation profile in tolerant kidney transplant patients.
Mélanie Chesneau,A. Pallier,Faouzi Braza,Faouzi Braza,gersende lacombe,S. Le Gallou,Daniel Baron,Magali Giral,Magali Giral,Richard Danger,Richard Danger,Pierrick Guerif,H. Aubert-Wastiaux,Antoine Néel,Antoine Néel,Laure Michel,Laure Michel,David-Axel Laplaud,David-Axel Laplaud,Nicolas Degauque,Jean-Paul Soulillou,Jean-Paul Soulillou,Karin Tarte,Sophie Brouard,Sophie Brouard +24 more
TL;DR: The data suggest that a balance between B cells producing IL‐10 and a deficiency in plasma cells may encourage an environment favorable to the tolerance maintenance, and down‐regulation of B cell differentiation genes and anti‐apoptotic B cell genes in these patients in vivo.
Journal ArticleDOI
Patients with relapsing-remitting multiple sclerosis have normal Treg function when cells expressing IL-7 receptor α-chain are excluded from the analysis
Laure Michel,Laureline Berthelot,Ségolène Pettré,Sandrine Wiertlewski,Fabienne Lefrère,Cécile Braudeau,Sophie Brouard,Jean-Paul Soulillou,David-Axel Laplaud +8 more
TL;DR: It is concluded that CD4+CD25highCD127low Tregs from MS patients and healthy individuals exhibit similar suppressive functions, possibly due to abnormal activation of CD127high T cells in patients with MS.