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Lauren Lepow
Researcher at Icahn School of Medicine at Mount Sinai
Publications - Â 18
Citations - Â 696
Lauren Lepow is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 12 publications receiving 258 citations.
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Journal ArticleDOI
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)
Conor Gruber,Roosheel S. Patel,Rebecca Trachtman,Lauren Lepow,Fatima Amanat,Florian Krammer,Karen M. Wilson,Kenan Onel,Daniel Geanon,Kevin Tuballes,Manishkumar Patel,Konstantinos Mouskas,Timothy O'Donnell,Elliot Merritt,Nicole W. Simons,Vanessa Barcessat,Diane Marie Del Valle,Samantha Udondem,Gurpawan Kang,Sandeep Gangadharan,George Ofori-Amanfo,Uri Laserson,Adeeb Rahman,Seunghee Kim-Schulze,Alexander W. Charney,Sacha Gnjatic,Bruce D. Gelb,Miriam Merad,Dusan Bogunovic +28 more
TL;DR: The auto-antigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal and immune-cell antigens.
Posted ContentDOI
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C).
Conor Gruber,Roosheel S. Patel,Rebecca Trachman,Lauren Lepow,Fatima Amanat,Florian Krammer,Karen M. Wilson,Kenan Onel,Daniel Geanon,Kevin Tuballes,Manishkumar Patel,Konstantinos Mouskas,Nicole W. Simons,Vanessa Barcessat,Diane Marie Del Valle,Samantha Udondem,Gurpawan Kang,Sandeep Gangadharan,George Ofori-Amanfo,Adeeb Rahman,Seunghee Kim-Schulze,Alexander W. Charney,Sacha Gnjatic,Bruce D. Gelb,Miriam Merad,Dusan Bogunovic +25 more
TL;DR: To assess the role for autoimmunity secondary to infection, the auto-antigen reactivity of MIS-C plasma was profiled, which revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal and immune-cell antigens.
Journal ArticleDOI
Extracting social determinants of health from electronic health records using natural language processing: a systematic review.
Braja Gopal Patra,Mohit Manoj Sharma,Veer Vekaria,Prakash Adekkanattu,Olga V. Patterson,Olga V. Patterson,Benjamin S. Glicksberg,Lauren Lepow,Euijung Ryu,Joanna M. Biernacka,Al'ona Furmanchuk,Thomas J. George,William R. Hogan,Yonghui Wu,Xi Yang,Jian-Guo Bian,Myrna M. Weissman,Priya Wickramaratne,J. John Mann,Mark Olfson,Thomas R. Campion,Mark G. Weiner,Jyotishman Pathak +22 more
TL;DR: A systematic review of state-of-the-art NLP approaches and tools that focus on identifying and extracting social determinants of health (SDoH) data from unstructured clinical text in EHRs is presented in this article.
Journal ArticleDOI
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Noam D. Beckmann,Phillip H. Comella,Esther Cheng,Lauren Lepow,Aviva G. Beckmann,Scott R. Tyler,Konstantinos Mouskas,Nicole W. Simons,Gabriel E. Hoffman,Nancy Francoeur,Diane Marie Del Valle,Gurpawan Kang,Anh N. Do,Emily Moya,Lillian Wilkins,Jessica Le Berichel,Christie Chang,Robert Marvin,Sharlene Calorossi,Alona Lansky,Laura Walker,Nancy Yi,Alex J. Yu,Jonathan H. Chung,Matthew Hartnett,Melody Eaton,Sandra Hatem,Hajra Jamal,Alara Akyatan,Alexandra Tabachnikova,Lora Liharska,Liam Cotter,Brian Fennessy,Akhil Vaid,Guillermo Barturen,Hardik Shah,Ying-Chih Wang,Shwetha Hara Sridhar,Juan C. Diaz Soto,Swaroop Bose,Kent Madrid,Ethan Ellis,Elyze Merzier,Konstantinos Vlachos,Nataly Fishman,Manying Tin,Melissa Smith,Hui Xie,Manishkumar Patel,Kai Nie +49 more
TL;DR: The authors performed RNA sequencing of blood from patients with multisystem inflammatory syndrome in children (MIS-C) and controls to find diseaseassociated genes clustered in a co-expression module annotated to CD56dimCD57+ natural killer (NK) cells and exhausted CD8+ T cells.
Journal ArticleDOI
Translating Molecular and Neuroendocrine Findings in Posttraumatic Stress Disorder and Resilience to Novel Therapies.
TL;DR: A critical review of select neurobiological findings in PTSD and resilience, and also of pharmacologic approaches that have emerged from this work, which involves engagement with targets in the adrenergic, hypothalamic-pituitary-adrenal axis, and neuropeptide Y systems.