Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)
Conor Gruber,Roosheel S. Patel,Rebecca Trachtman,Lauren Lepow,Fatima Amanat,Florian Krammer,Karen M. Wilson,Kenan Onel,Daniel Geanon,Kevin Tuballes,Manishkumar Patel,Konstantinos Mouskas,Timothy O'Donnell,Elliot Merritt,Nicole W. Simons,Vanessa Barcessat,Diane Marie Del Valle,Samantha Udondem,Gurpawan Kang,Sandeep Gangadharan,George Ofori-Amanfo,Uri Laserson,Adeeb Rahman,Seunghee Kim-Schulze,Alexander W. Charney,Sacha Gnjatic,Bruce D. Gelb,Miriam Merad,Dusan Bogunovic +28 more
Reads0
Chats0
TLDR
The auto-antigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal and immune-cell antigens.About:
This article is published in Cell.The article was published on 2020-11-12 and is currently open access. It has received 396 citations till now. The article focuses on the topics: Immune dysregulation & Autoantibody.read more
Citations
More filters
Journal ArticleDOI
Adaptive immunity to SARS-CoV-2 and COVID-19.
TL;DR: In this article, a picture has begun to emerge that reveals that CD4+ T cells, CD8+ Tcells, and neutralizing antibodies all contribute to control SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19.
Journal ArticleDOI
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Camila Rosat Consiglio,Nicola Cotugno,Nicola Cotugno,Fabian Sardh,Christian Pou,Donato Amodio,Donato Amodio,Lucie Rodriguez,Ziyang Tan,Sonia Zicari,Alessandra Ruggiero,Giuseppe Rubens Pascucci,Veronica Santilli,Tessa M. Campbell,Yenan T. Bryceson,Daniel Eriksson,Daniel Eriksson,Jun Wang,Alessandra Marchesi,Tadepally Lakshmikanth,Andrea Campana,Alberto Villani,Paolo Rossi,Paolo Rossi,Nils Landegren,Nils Landegren,Paolo Palma,Paolo Palma,Petter Brodin,Petter Brodin +29 more
TL;DR: The inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage.
Journal ArticleDOI
COVID-19 and multisystem inflammatory syndrome in children and adolescents.
Li Jiang,Kun Tang,Michael Levin,Omar Irfan,Shaun K. Morris,Karen M. Wilson,Jonathan D. Klein,Zulfiqar A Bhutta +7 more
TL;DR: In this paper, the authors reviewed the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19.
Journal ArticleDOI
COVID-19 and the human innate immune system.
TL;DR: In this article, a conceptual framework for the interaction of the human innate immune system with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was provided to link the clinical observations with experimental findings that have been made during the first year of the pandemic.
Journal ArticleDOI
Immune determinants of COVID-19 disease presentation and severity.
Petter Brodin,Petter Brodin +1 more
TL;DR: In this article, the authors discuss the immunological determinants of COVID-19 disease presentation and severity and relate this to known immune-system differences between young and old people and between men and women, and other factors associated with different disease presentations and severity.
References
More filters
Journal Article
R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
TL;DR: This work presents DESeq2, a method for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates, which enables a more quantitative analysis focused on the strength rather than the mere presence of differential expression.
Journal ArticleDOI
Fast gapped-read alignment with Bowtie 2
TL;DR: Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy.
Journal ArticleDOI
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Related Papers (5)
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents.
Leora R. Feldstein,Leora R. Feldstein,Erica B. Rose,Erica B. Rose,Steven M. Horwitz,Jennifer P. Collins,Margaret M Newhams,Mary Beth F. Son,Jane W. Newburger,Lawrence C. Kleinman,Sabrina M. Heidemann,Amarilis A. Martin,Aalok R. Singh,Simon Li,Keiko M. Tarquinio,Preeti Jaggi,Matthew E. Oster,Sheemon P. Zackai,Jennifer K. Gillen,Adam J. Ratner,Rowan Walsh,Julie C. Fitzgerald,Michael A. Keenaghan,Hussam Alharash,Sule Doymaz,Katharine N. Clouser,John S. Giuliano,Anjali Gupta,Robert M. Parker,Aline B Maddux,Vinod Havalad,Stacy Ramsingh,Hulya Bukulmez,Tamara T. Bradford,Lincoln S. Smith,Mark W Tenforde,Christopher L. Carroll,Becky J. Riggs,Shira J. Gertz,Ariel Daube,Amanda N Lansell,Alvaro Coronado Munoz,Charlotte V. Hobbs,Kimberly Marohn,Natasha B. Halasa,Manish M. Patel,Manish M. Patel,Adrienne G. Randolph +47 more
Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.
Elizabeth Whittaker,Elizabeth Whittaker,Alasdair Bamford,Alasdair Bamford,Julia Kenny,Julia Kenny,Myrsini Kaforou,Christine E. Jones,Priyen Shah,Padmanabhan Ramnarayan,Padmanabhan Ramnarayan,Alain Fraisse,Owen G. Miller,Owen G. Miller,Patrick Davies,Filip Kucera,Joe Brierley,Marilyn McDougall,Marilyn McDougall,Michael J. Carter,Michael J. Carter,Adriana H. Tremoulet,Chisato Shimizu,Jethro Herberg,Jethro Herberg,Jane C. Burns,Hermione Lyall,Michael Levin +27 more