L
Laurence D. Hurst
Researcher at University of Bath
Publications - 310
Citations - 24738
Laurence D. Hurst is an academic researcher from University of Bath. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 76, co-authored 296 publications receiving 22836 citations. Previous affiliations of Laurence D. Hurst include University of Chicago & University of Oxford.
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Journal ArticleDOI
Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance
Matthew T. G. Holden,Edward J. Feil,Jodi A. Lindsay,Sharon J. Peacock,Nicholas P. J. Day,Mark C. Enright,Timothy J. Foster,Catrin E. Moore,Laurence D. Hurst,Rebecca Atkin,Andrew Barron,Nathalie Bason,Stephen D. Bentley,Carol Chillingworth,Tracey Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Jon Doggett,Linda Dowd,Theresa Feltwell,Zahra Hance,Barbara Harris,Heidi Hauser,S. Holroyd,Kay Jagels,Keith D. James,Nicola Lennard,Alexandra Line,Rebecca Mayes,Sharon Moule,Karen Mungall,Douglas Ormond,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Mandy Sanders,Sarah Sharp,Mark Simmonds,K. Stevens,Sally Whitehead,Bart Barrell,Brian G. Spratt,Julian Parkhill +44 more
TL;DR: The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains.
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Dosage sensitivity and the evolution of gene families in yeast
TL;DR: The hypothesis that dominance is a by-product of physiology and metabolism rather than the result of selection to mask the deleterious effects of mutations is supported, as it is found that members of large gene families are rarely involved in complexes.
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Hearing silence: non-neutral evolution at synonymous sites in mammals
TL;DR: New evidence indicates that even some synonymous mutations are subject to constraint, often because they affect splicing and/or mRNA stability, which has implications for understanding disease, optimizing transgene design, detecting positive selection and estimating the mutation rate.
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The evolutionary dynamics of eukaryotic gene order
TL;DR: Evidence that genes that have similar and/or coordinated expression are often clustered is reviewed and it is asked how such clusters evolve and how this relates to mechanisms that control gene expression.