Journal ArticleDOI
The evolutionary dynamics of eukaryotic gene order
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TLDR
Evidence that genes that have similar and/or coordinated expression are often clustered is reviewed and it is asked how such clusters evolve and how this relates to mechanisms that control gene expression.Abstract:
In eukaryotes, unlike in bacteria, gene order has typically been assumed to be random. However, the first statistically rigorous analyses of complete genomes, together with the availability of abundant gene-expression data, have forced a paradigm shift: in every complete eukaryotic genome that has been analysed so far, gene order is not random. It seems that genes that have similar and/or coordinated expression are often clustered. Here, we review this evidence and ask how such clusters evolve and how this relates to mechanisms that control gene expression.read more
Citations
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Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
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lincRNAs act in the circuitry controlling pluripotency and differentiation
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TL;DR: It is shown that Knockdown of lincRNAs has major consequences on gene expression patterns, comparable to knockdown of well-known ES cell regulators.
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References
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TL;DR: The genome-wide characterization of mRNA transcript levels during the cell cycle of the budding yeast S. cerevisiae indicates a mechanism for local chromosomal organization in global mRNA regulation and links a range of human genes to cell cycle period-specific biological functions.
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