Laurence D. Hurst

TL;DR: The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains.

TL;DR: The hypothesis that dominance is a by-product of physiology and metabolism rather than the result of selection to mask the deleterious effects of mutations is supported, as it is found that members of large gene families are rarely involved in complexes.

TL;DR: New evidence indicates that even some synonymous mutations are subject to constraint, often because they affect splicing and/or mRNA stability, which has implications for understanding disease, optimizing transgene design, detecting positive selection and estimating the mutation rate.

TL;DR: Evidence that genes that have similar and/or coordinated expression are often clustered is reviewed and it is asked how such clusters evolve and how this relates to mechanisms that control gene expression.