L
Lawrence W. Elmer
Researcher at University of Michigan
Publications - 4
Citations - 7700
Lawrence W. Elmer is an academic researcher from University of Michigan. The author has contributed to research in topics: Huntington's disease & Dopaminergic. The author has an hindex of 4, co-authored 4 publications receiving 7215 citations.
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Journal ArticleDOI
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
Journal ArticleDOI
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues.
Theresa V. Strong,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Karina Boehm,Manju Swaroop,Kevin W. Kaatz,Francis S. Collins,Roger L. Albin +8 more
TL;DR: The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.
Journal ArticleDOI
Expression and regulation of the human dopamine transporter in a neuronal cell line
TL;DR: A neuronal model system expressing the human DAT transfected into Neuro2A cells found that dopamine uptake was down-regulated by treatment with a PKC activator and should be useful for ongoing experiments examining the regulation of the DAT by assorted treatments.